4-methyl-N-phenyl-6-(3-fluorophenyl)-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-N-phenyl-6-(3-fluorophenyl)-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamide
• 英文别名: 4-(3-fluorophenyl)-6-methyl-2-oxo-N-phenyl-3,4-dihydro-1H-pyrimidine-5-carboxamide
• 化学式: C₁₈H₁₆FN₃O₂
• 分子量: 325.342
• InChiKey: KBACMQAFVWHKNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  70.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-乙酰乙酰苯胺 、 尿素 、 3-氟苯甲醛 以84%的产率得到4-methyl-N-phenyl-6-(3-fluorophenyl)-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamide
  参考文献：
  名称：

  Synthesis, structure, and antimicrobial activity of N,6-diaryl-4-methyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides

  摘要：

  Reactions of acetoacetic acid N-arylamides with aromatic aldehydes and urea led to the formation of N,6-diaryl-4-methyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. Structure and antimicrobial activity of the compounds obtained were examined.

  DOI：

  10.1134/s1070363216110062

文献信息

• Synthesis, structure, and antimicrobial activity of N,6-diaryl-4-methyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides
  作者：V. L. Gein、T. M. Zamaraeva、A. Yu. Fedotov、A. V. Balandina、M. V. Dmitriev

  DOI：10.1134/s1070363216110062

  日期：2016.11

  Reactions of acetoacetic acid N-arylamides with aromatic aldehydes and urea led to the formation of N,6-diaryl-4-methyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. Structure and antimicrobial activity of the compounds obtained were examined.