制皮菌素 | 11120-15-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 中文名称: 制皮菌素
• 英文名称: Dermostatin-A
• 英文别名: Dermostatin；(3E,5E,7E,9E,11E,13E,33E)-16,18,20,22,24,26,28,30,32-nonahydroxy-17,35-dimethyl-36-propan-2-yl-1-oxacyclohexatriaconta-3,5,7,9,11,13,33-heptaen-2-one
• CAS: 11120-15-3
• 化学式: C₄₀H₆₄O₁₁
• 分子量: 720.942
• InChiKey: LSYAYTGVPHMMBZ-VMYRXBQLSA-N

物化性质

• 比旋光度：
  D -82° (c = 0.2 in methanol)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  51
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  208
• 氢给体数：
  9
• 氢受体数：
  11

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF FUNGAL INFECTIONS<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT D'INFECTIONS FONGIQUES
  申请人：CIDARA THERAPEUTICS INC

  公开号：WO2015164289A1

  公开（公告）日：2015-10-29

  Compositions and methods for the treatment of fungal infections including compounds containing a chemotaxis receptor ligand moiety and a polyene antifungal agent moiety are disclosed. In particular, compounds containing a polyene antifungal agent and a formyl peptide receptor ligand can be used in the treatment of fungal infections caused by a fungus of the genus Aspergillus or Candida.

  揭示了用于治疗真菌感染的化合物和方法，包括含有趋化受体配体基团和聚烯抗真菌剂基团的化合物。具体来说，含有聚烯抗真菌剂和甲酰肽受体配体的化合物可用于治疗由曲霉属或白念珠菌属真菌引起的真菌感染。
• Compositions comprising cyclodextrins and NO- releasing drugs
  申请人：NICOX S.A.

  公开号：EP1219306A1

  公开（公告）日：2002-07-03

  The present invention relates to composition comprising cyclodextrins and a NO-releasing drug of formula         A-X-L-NOn wherein A is the radical deriving from a drug; X is a divalent radical connecting A with the NO-releasing group L-NOn; L is selected from the group consisting of: O and S; n is 1 or 2.

  本发明涉及由环糊精和式 A-X-L-NOn 的 NO 释放药物组成的组合物。 A-X-L-NOn 其中 A 是源自药物的自由基； X 是连接 A 与释放 NO 基团 L-NOn 的二价自由基； L 选自以下组成的组O和S；n为1或2。
• Methods for preventing and treating pneumocystis infections
  申请人：Cidara Therapeutics, Inc.

  公开号：US10369188B2

  公开（公告）日：2019-08-06

  The disclosure relates to methods of prophylactic and therapeutic treatments of a Pneumocystis infection (i.e., an infection caused by Pneumocystis jirovecii) in a subject by administering to the subject a compound of any of formulas (1)-(111) (e.g., a salt of Compound 1, or a neutral form thereof). The disclosure also relates to methods of inhibiting the replication of a Pneumocystis spp. The methods of the disclosure can be useful in immunocompromized subjects.

  本发明涉及通过向受试者施用式(1)-(111)中任何一种化合物（例如，化合物1的盐或其中性形式）来预防和治疗受试者肺孢子虫感染（即由肺孢子虫引起的感染）的方法。本公开还涉及抑制肺孢子虫属复制的方法。 本公开的方法可用于免疫功能低下的受试者。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto
  申请人：The University of North Carolina at Chapel Hill

  公开号：US11026965B2

  公开（公告）日：2021-06-08

  Disclosed herein are cyclodextrin molecules covalently modified to store and release nitric oxide, as well as methods of making and uses thereof. The covalently modified cyclodextrin molecules may be tailored, in several embodiments, to release nitric oxide in a controlled manner and are useful for reduction and/or eradication of bacteria and for the treatment of disease.

  本文公开了经共价修饰以储存和释放一氧化氮的环糊精分子及其制造方法和用途。在多个实施例中，共价修饰的环糊精分子可定制为以受控方式释放一氧化氮，可用于减少和/或消灭细菌以及治疗疾病。