HESA

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: HESA
• 英文别名: 4-(2-Hydroxyethoxy)-3,5-dimethoxybenzoic acid
• 化学式: C₁₁H₁₄O₆
• mdl: MFCD08696450
• 分子量: 242.229
• InChiKey: YIQGHBULUKKKQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  丁香酸 、 2-氯乙醇 在 sodium iodide 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 96.0h， 以67%的产率得到HESA
  参考文献：
  名称：

  内酯和生物芳烃通过同时开环聚合/缩聚的共聚

  摘要：

  内酯和生物芳族羟基酸的同时开环聚合/缩聚反应产生具有改善和受控的热性能的无规共聚物。

  DOI：

  10.1039/c6gc03238a

文献信息

• ANTIVIRAL COMPOUNDS
  申请人：Alios BioPharma, Inc.

  公开号：US20160244460A1

  公开（公告）日：2016-08-25

  Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

  本文披露了新的抗病毒化合物，以及包括一个或多个抗病毒化合物的药物组合物，以及合成这些化合物的方法。本文还披露了使用一个或多个小分子化合物改善和/或治疗副粘病毒病毒感染的方法。副粘病毒感染的例子包括由人类呼吸道合胞病毒（RSV）引起的感染。
• METHOD FOR PRODUCING POLYESTER
  申请人：Riken

  公开号：EP3296342A1

  公开（公告）日：2018-03-21

  Provided is a method for producing a non-colored polyester with a high molecular weight. The method is to produce a polyester represented by a general formula (2). This method comprises: a first step of heating, under the presence of an antimony catalyst, a compound represented by the general formula (1) at a heating temperature in a range of from a melting point of the compound to a temperature that is 10°C higher than the melting point; and a second step of heating a solid product or viscous product obtained after the first step at a heating temperature in a range of from the melting point of the compound represented by the general formula (1) to 270°C. In the general formula (1), Z represents a divalent hydrocarbon group having 1 to 12 carbon atoms; R1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or a phenyl group; R2 represents a methyl group or an ethyl group; and m represents an integer of 0 to 2. In the general formula (2), Z, R2 and m are defined as above in the general formula (1), and n represents an average repeating unit number satisfying n=10 to 600.

  本发明提供了一种生产高分子量无色聚酯的方法。该方法用于生产通式（2）所代表的聚酯。该方法包括：第一步，在锑催化剂存在下，加热通式（1）所代表的化合物，加热温度范围从化合物的熔点到比熔点高 10°C 的温度；第二步，加热第一步后得到的固体产品或粘稠产品，加热温度范围从通式（1）所代表的化合物的熔点到 270°C。在通式(1)中，Z 代表具有 1 至 12 个碳原子的二价烃基；R1 代表氢原子、具有 1 至 6 个碳原子的烷基或苯基；R2 代表甲基或乙基；m 代表 0 至 2 的整数。在通式(2)中，Z、R2 和 m 的定义与通式(1)中的定义相同，n 代表满足 n=10 至 600 的平均重复单元数。
• Method for producing polyester
  申请人：RIKEN

  公开号：US10351667B2

  公开（公告）日：2019-07-16

  Provided is a method for producing a non-colored polyester with a high molecular weight. The method is to produce a polyester represented by a general formula (2). This method comprises: a first step of heating, under the presence of an antimony catalyst, a compound represented by the general formula (1) at a heating temperature in a range of from a melting point of the compound to a temperature that is 10° C. higher than the melting point; and a second step of heating a solid product or viscous product obtained after the first step at a heating temperature in a range of from the melting point of the compound represented by the general formula (1) to 270° C.

  本发明提供了一种生产高分子量无色聚酯的方法。该方法用于生产通式（2）所代表的聚酯。该方法包括：第一步，在锑催化剂存在下，加热通式（1）表示的化合物，加热温度范围为化合物熔点至比熔点高 10 摄氏度的温度；第二步，加热第一步后得到的固体产品或粘稠产品，加热温度范围为通式（1）表示的化合物熔点至 270 摄氏度。
• Antiviral compounds
  申请人：Alios BioPharma, Inc.

  公开号：US10358453B2

  公开（公告）日：2019-07-23

  Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

  本文公开了新的抗病毒化合物，以及包括一种或多种抗病毒化合物的药物组合物和合成这些化合物的方法。本文还公开了用一种或多种小分子化合物改善和/或治疗副黏液病毒感染的方法。副粘病毒感染的例子包括由人类呼吸道合胞病毒（RSV）引起的感染。
• Copolymerization of lactones and bioaromatics via concurrent ring-opening polymerization/polycondensation
  作者：Ha Thi Hoang Nguyen、Gabriel N. Short、Pengxu Qi、Stephen A. Miller

  DOI：10.1039/c6gc03238a

  日期：——

  Concurrent ring-opening polymerization/polycondensation of lactones and bioaromatic hydroxy-acids yields random copolymers with improved and controlled thermal properties.

  内酯和生物芳族羟基酸的同时开环聚合/缩聚反应产生具有改善和受控的热性能的无规共聚物。