1-butoxy-3-(4-chlorophenylthio)propan-2-ol

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 1-butoxy-3-(4-chlorophenylthio)propan-2-ol
• 英文别名: 1-Butoxy-3-(4-chlorophenyl)sulfanylpropan-2-ol
• 化学式: C₁₃H₁₉ClO₂S
• 分子量: 274.812
• InChiKey: CGUPHVLVFASEHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.538
• 拓扑面积：
  54.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  正丁基缩水甘油醚 、 4-氯苯硫酚 在 iron(II,III) oxide 作用下， 反应 0.33h， 以90%的产率得到1-butoxy-3-(4-chlorophenylthio)propan-2-ol
  参考文献：
  名称：

  Recyclable superparamagnetic Fe3O4 nanoparticles for efficient catalysis of thiolysis of epoxides

  摘要：

  An efficient and rapid procedure is developed for room-temperature ring opening of various epoxides with thiols under solvent-free conditions in the presence of catalytic amount of superparamagnetic Fe3O4 nanoparticles. As a result, high conversion of reactants to various beta-hydroxy sulfides is observed in short time periods while the heterogeneous catalyst could be recovered and reused over several cycles without loosing its activity. Competitive reactions show higher reactivity of aromatic thiols over the aliphatic counterparts. (c) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2012.05.004

文献信息

• Recyclable superparamagnetic Fe3O4 nanoparticles for efficient catalysis of thiolysis of epoxides
  作者：Mohammad M. Mojtahedi、M. Saeed Abaee、Azam Rajabi、Peyman Mahmoodi、Saeed Bagherpoor

  DOI：10.1016/j.molcata.2012.05.004

  日期：2012.9

  An efficient and rapid procedure is developed for room-temperature ring opening of various epoxides with thiols under solvent-free conditions in the presence of catalytic amount of superparamagnetic Fe3O4 nanoparticles. As a result, high conversion of reactants to various beta-hydroxy sulfides is observed in short time periods while the heterogeneous catalyst could be recovered and reused over several cycles without loosing its activity. Competitive reactions show higher reactivity of aromatic thiols over the aliphatic counterparts. (c) 2012 Elsevier B.V. All rights reserved.
• Additive‐Free Thiolysis of Epoxides in Water: A Green and Efficient Regioselective Pathway to β‐Hydroxy Sulfides
  作者：Saeed M. Abaee、Mohammad M. Mojtahedi、Hassan Abbasi、Ensieh R. Fatemi

  DOI：10.1080/00397910701749963

  日期：2008.1

  Room-temperature ring opening of various epoxides with aromatic thiols was carried out in water in the absence of any Lewis acid or additive. High yields of beta-hydroxy sulfides with excellent regioselectivity were obtained under very environmentally friendly conditions.
• Rapid, benign, and additive-free thiolysis of epoxides under ultrasonic/aqueous conditions
  作者：Mohammad M. Mojtahedi、Sajad Khalili

  DOI：10.1080/17415993.2014.909814

  日期：2014.7.4

  An environmentally friendly and efficient procedure is developed for ring opening of various epoxides with thiols under non-thermal conditions. Reactions take place by ultrasonic irradiation of the two reactants suspended in an additive-free aqueous medium. Consequently, high-yield formation of various beta-hydroxy sulfides is quickly observed.[GRAPHICS].