1,1,8,8-tetraphenyloctane-2,7-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1,8,8-tetraphenyloctane-2,7-dione
• 化学式: C₃₂H₃₀O₂
• 分子量: 446.589
• InChiKey: XIJUROXAALUUAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-benzhydrylcyclopropan-1-ol 在 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 silver carbonate 作用下， 以 2,2,2-三氟乙醇 为溶剂， 反应 0.25h， 以62%的产率得到1,1,8,8-tetraphenyloctane-2,7-dione
  参考文献：
  名称：

  Rhodium-Catalyzed Room Temperature C–C Activation of Cyclopropanol for One-Step Access to Diverse 1,6-Diketones

  摘要：

  A rhodium-catalyzed room temperature C-C activation of cyclopropanol has been demonstrated for the single-step synthesis of a range of electronically and sterically distinct 1,6-diketones. This reaction proceeds efficiently in shorter reaction time following a highly atom-economical pathway. To illustrate the synthetic potential of 1,6-diketones, aldol and macrocyclization reactions have been successfully demonstrated. Preliminary mechanistic studies revealed the involvement of nonradical pathways.

  DOI：

  10.1021/acs.orglett.0c00967

文献信息

• Low-valent titanium induced reductive coupling reaction of carboxylic derivatives with aromatic ketones
  作者：Da-qing Shi、Jian-xie Chen、Wen-ying Chai、Wei-xing Chen、Tsi-yu Kao

  DOI：10.1016/s0040-4039(00)60493-8

  日期：1993.4

  The intermolecular and intramolecular coupling reaction of carboxylic derivaties with aromatic ketones induced by titanium tetrachloride and zinc powder was studied.

  研究了四氯化钛和锌粉诱导的羧酸衍生物与芳族酮的分子间和分子内偶联反应。
• Intermolecular reductive cross coupling of carbonyl compounds with nitriles induced by low-valent titanium
  作者：Ju Gao、Ming-yang Hu、Jian-xie Chen、Su Yuan、Wei-xing Chen

  DOI：10.1016/0040-4039(93)85023-p

  日期：1993.3

  Intermolecular cross coupling of carbonyl compounds with nitriles promoted by TiCl4-Zn leads to ketones.

  TiCl 4 -Zn促进的羰基化合物与腈的分子间交叉偶联导致生成酮。
• Rhodium-Catalyzed Room Temperature C–C Activation of Cyclopropanol for One-Step Access to Diverse 1,6-Diketones
  作者：Bedadyuti Vedvyas Pati、Asit Ghosh、P. C. Ravikumar

  DOI：10.1021/acs.orglett.0c00967

  日期：2020.4.3

  A rhodium-catalyzed room temperature C-C activation of cyclopropanol has been demonstrated for the single-step synthesis of a range of electronically and sterically distinct 1,6-diketones. This reaction proceeds efficiently in shorter reaction time following a highly atom-economical pathway. To illustrate the synthetic potential of 1,6-diketones, aldol and macrocyclization reactions have been successfully demonstrated. Preliminary mechanistic studies revealed the involvement of nonradical pathways.