1,4-Dihydro-4-[3-[[3-chloro-1-oxo-1-propyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid, dimethyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,4-Dihydro-4-[3-[[3-chloro-1-oxo-1-propyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid, dimethyl ester
• 英文别名: dimethyl 4-[3-(3-chloropropanoylamino)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• 化学式: C₂₀H₂₃ClN₂O₅
• 分子量: 406.866
• InChiKey: OWMOZUYQDLKJKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  93.7
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,4-dihydro-4-(3-aminophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid,dimethyl ester 、 3-氯丙酰氯 在 Dichloromethane brine 、 二氯甲烷 、 Sodium sulfate-III 、 Silica gel 、 乙酸乙酯 、 正己烷 作用下， 以 四氢呋喃 为溶剂， 反应 1.17h， 以Silica gel chromatography (1:1 to 1:0 EtOAc:hexane gradient) gave the title compound (1.05 g, 100%) as a pale yellow foam的产率得到1,4-Dihydro-4-[3-[[3-chloro-1-oxo-1-propyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid, dimethyl ester
  参考文献：
  名称：

  Dihydropyridine npy antagonists: piperazine derivatives

  摘要：

  一系列非肽类NPY拮抗剂已被合成，包括公式（I）的4-苯基-1,4-二氢吡啶的哌嗪和同型哌嗪衍生物。由于这些化合物作为NPY诱导的进食行为的拮抗剂，预计它们将作为有效的厌食剂促进减重并治疗进食障碍。

  公开号：

  US05635503A1

文献信息

• Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives
  申请人：Bristol-Myers Squibb Company

  公开号：US05554621A1

  公开（公告）日：1996-09-10

  A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of nitrogen heterocyclic derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

  一系列非肽类NPY拮抗剂已经合成，由Formula (I)的4-苯基-1,4-二氢吡啶的氮杂环衍生物组成。作为NPY诱导的进食行为的拮抗剂，预计这些化合物将作为有效的压食剂，在促进减重和治疗进食障碍方面发挥作用。
• Dihydropyridine NPY antagonists: piperidine derivatives
  申请人：Bristol-Myers Squibb Company

  公开号：US05668151A1

  公开（公告）日：1997-09-16

  A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperidine and tetrahydropyridine derivatives of 4-phenyl-1,4-dihydropyridines of Formula I. ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

  一系列非肽类NPY拮抗剂已经合成，由Formula I的哌啶和四氢吡啶衍生物以及4-苯基-1,4-二氢吡啶组成。作为NPY诱导的进食行为的拮抗剂，预计这些化合物将作为有效的压食剂，促进减重和治疗进食障碍。
• Dihydropyridine npy antagonists: piperazine derivatives
  申请人：Bristol-Myers Squibb Company

  公开号：US05635503A1

  公开（公告）日：1997-06-03

  A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperazine and homopiperazine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

  一系列非肽类NPY拮抗剂已经合成，由式(I)的4-苯基-1,4-二氢吡啶的哌嗪和同哌嗪衍生物组成。作为NPY诱导的进食行为的拮抗剂，预计这些化合物将作为有效的压食剂药物，促进减重和治疗进食障碍。