isoquinolin-1-yl(3-phenoxyphenyl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: isoquinolin-1-yl(3-phenoxyphenyl)methanone
• 英文别名: Isoquinolin-1-yl-(3-phenoxyphenyl)methanone；isoquinolin-1-yl-(3-phenoxyphenyl)methanone
• 化学式: C₂₂H₁₅NO₂
• 分子量: 325.367
• InChiKey: UAWCNZWBCORAPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  异喹啉 、 间苯氧基苯甲醛 在 叔丁基过氧化氢 、 N-氯代丁二酰亚胺 作用下， 以 癸烷 、 1,2-二氯乙烷 为溶剂， 反应 15.0h， 以56%的产率得到isoquinolin-1-yl(3-phenoxyphenyl)methanone
  参考文献：
  名称：

  Transition metal-free Minisci reaction promoted by NCS, and TBHP: acylation of heteroarenes

  摘要：

  A method for acylation for heteroarenes under metal-free conditions has been described using NCS as an additive and TBHP as an oxidant. This method has been successfully employed in acylation of a variety of aldehyde with heteroarenes. The application of the method has been illustrated in synthesizing isoquinoline derived natural products. This strategy provides an efficient, mild and inexpensive method for acylation of heteroarenes. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.12.065

文献信息

• Transition metal-free Minisci reaction promoted by NCS, and TBHP: acylation of heteroarenes
  作者：Yogesh Siddaraju、Kandikere Ramaiah Prabhu

  DOI：10.1016/j.tet.2015.12.065

  日期：2016.2

  A method for acylation for heteroarenes under metal-free conditions has been described using NCS as an additive and TBHP as an oxidant. This method has been successfully employed in acylation of a variety of aldehyde with heteroarenes. The application of the method has been illustrated in synthesizing isoquinoline derived natural products. This strategy provides an efficient, mild and inexpensive method for acylation of heteroarenes. (C) 2015 Elsevier Ltd. All rights reserved.