2-amino-4-[(2-chloro-6-methylpyrimidin-4-yl)thio]-6-methylpyrimidine

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-amino-4-[(2-chloro-6-methylpyrimidin-4-yl)thio]-6-methylpyrimidine
• 英文别名: 4-[(2-Chloro-6-methylpyrimidin-4-yl)sulfanyl]-6-methylpyrimidin-2-amine；4-(2-chloro-6-methylpyrimidin-4-yl)sulfanyl-6-methylpyrimidin-2-amine
• 化学式: C₁₀H₁₀ClN₅S
• mdl: MFCD05241175
• 分子量: 267.742
• InChiKey: HTBJVPXIFJWAES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-amino-4-[(2-chloro-6-methylpyrimidin-4-yl)thio]-6-methylpyrimidine 在 hydrazine hydrate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 24.0h， 以73%的产率得到2-amino-4-[(2-hydrazinyl-6-methylpyrimidin-4-yl)thio]-6-methylpyrimidine
  参考文献：
  名称：

  Synthesis and Plant Growth Stimulating Action of 2-Amino-6-methylpyrimidine-4(3H)-thione Derivatives

  摘要：

  A series of new pyrimidine derivatives, including those containing an azole or azine heterocycle linked through a sulfur atom or a thiomethylene group, was synthesized based on 2-amino-6-methylpyrimidine-4(3H)-thione. The synthesized compounds exhibited a pronounced stimulating effect on plants growth in the range of 43-96% compared to heteroauxin.

  DOI：

  10.1134/s1070363220020073
• 作为产物：
  描述：

  2,4-二氯-6-甲基嘧啶 、 以 N,N-二甲基甲酰胺 为溶剂， 以67%的产率得到2-amino-4-[(2-chloro-6-methylpyrimidin-4-yl)thio]-6-methylpyrimidine
  参考文献：
  名称：

  Synthesis and Plant Growth Stimulating Action of 2-Amino-6-methylpyrimidine-4(3H)-thione Derivatives

  摘要：

  A series of new pyrimidine derivatives, including those containing an azole or azine heterocycle linked through a sulfur atom or a thiomethylene group, was synthesized based on 2-amino-6-methylpyrimidine-4(3H)-thione. The synthesized compounds exhibited a pronounced stimulating effect on plants growth in the range of 43-96% compared to heteroauxin.

  DOI：

  10.1134/s1070363220020073

文献信息

• Synthesis and Plant Growth Stimulating Action of 2-Amino-6-methylpyrimidine-4(3H)-thione Derivatives
  作者：E. N. Hambardzumyan、A. S. Vorskanyan、L. V. Shahbazyan、A. P. Yengoyan

  DOI：10.1134/s1070363220020073

  日期：2020.2

  A series of new pyrimidine derivatives, including those containing an azole or azine heterocycle linked through a sulfur atom or a thiomethylene group, was synthesized based on 2-amino-6-methylpyrimidine-4(3H)-thione. The synthesized compounds exhibited a pronounced stimulating effect on plants growth in the range of 43-96% compared to heteroauxin.