1-diphenylphosphinoyl-1-cyclopropanecarboxylic acid diethylamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-diphenylphosphinoyl-1-cyclopropanecarboxylic acid diethylamide
• 英文别名: 1-diphenylphosphinyl-1-cyclopropanecarboxylic acid diethylamide；1-(Diphenylphosphoroso)-NN-diethylcyclopropane-1-carboxamide；1-diphenylphosphoryl-N,N-diethylcyclopropane-1-carboxamide
• 化学式: C₂₀H₂₄NO₂P
• mdl: MFCD01461681
• 分子量: 341.39
• InChiKey: VMHDOZRHLNVYEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-diphenylphosphinylcyclopropanecarboxilic acid 在 吡啶 、 氯化亚砜 作用下， 以 氯仿 为溶剂， 反应 2.0h， 生成 1-diphenylphosphinoyl-1-cyclopropanecarboxylic acid diethylamide
  参考文献：
  名称：

  Some properties of 1-phosphorus(IV)-substituted cycloalkanecarboxylic acids and their derivatives

  摘要：

  An x-ray structural study of single crystals of 1-diphenylphosphinyl-cyclo-propane- and 1-diphenylphosphinylcyclobutanecarboxylic acids was conducted. 1-Phosphorylated cycloalkanecarboxylic acid amides were obtained from the corresponding acids by the reaction with thionyl chloride with subsequent treatment with primary and secondary amines. It was shown that the reaction of 1-phosphorylated 1-functional substituted cycloalkanes with trimethylbromosilane takes place with preservation of the cyclic structure and yields phosphoric acid silyl esters, and the corresponding cycloalkylphosphonic and cycloalkylphosphinic acids were synthesized by their hydrolysis in soft conditions.

  DOI：

  10.1007/bf00864348

文献信息

• Turanov; Kharitonov; Yarkevich, Russian Journal of General Chemistry, 1999, vol. 69, # 7, p. 1052 - 1055
  作者：Turanov、Kharitonov、Yarkevich、Evseeva、Safronova、Tsvetkov

  DOI：——

  日期：——
• Some properties of 1-phosphorus(IV)-substituted cycloalkanecarboxylic acids and their derivatives
  作者：I. L. Odinets、P. V. Kazakov、R. U. Amanov、M. Yu. Antipin、L. V. Kovalenko、Yu. T. Struchkov、T. A. Mastryukova

  DOI：10.1007/bf00864348

  日期：1992.8

  An x-ray structural study of single crystals of 1-diphenylphosphinyl-cyclo-propane- and 1-diphenylphosphinylcyclobutanecarboxylic acids was conducted. 1-Phosphorylated cycloalkanecarboxylic acid amides were obtained from the corresponding acids by the reaction with thionyl chloride with subsequent treatment with primary and secondary amines. It was shown that the reaction of 1-phosphorylated 1-functional substituted cycloalkanes with trimethylbromosilane takes place with preservation of the cyclic structure and yields phosphoric acid silyl esters, and the corresponding cycloalkylphosphonic and cycloalkylphosphinic acids were synthesized by their hydrolysis in soft conditions.