(E)-3-([1,1'-biphenyl]-4-yl)-1-(3,4-dimethoxyphenyl)prop-2-en-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: (E)-3-([1,1'-biphenyl]-4-yl)-1-(3,4-dimethoxyphenyl)prop-2-en-1-one
• 英文别名: (E)-1-(3,4-dimethoxyphenyl)-3-(4-phenylphenyl)prop-2-en-1-one
• 化学式: C₂₃H₂₀O₃
• 分子量: 344.41
• InChiKey: DKMDWATVOKBHAL-GXDHUFHOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对苯基苯甲醛 、 3,4-二甲氧基苯乙酮 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 生成 (E)-3-([1,1'-biphenyl]-4-yl)-1-(3,4-dimethoxyphenyl)prop-2-en-1-one
  参考文献：
  名称：

  Synthesis of apoptotic chalcone analogues in HepG2 human hepatocellular carcinoma cells

  摘要：

  Eight chalcone analogues were prepared and evaluated for their cytotoxic effects in human hepatoma HepG2 cells. Compound 5 had a potent cytotoxic effect. The percentage of apoptotic cells was significantly higher in compound 5-treated cells than in control cells. Exposure to compound 5 for 24 h induced cleavage of caspase-8 and -3, and poly (ADP-ribose) polymerase (PARP). Our findings suggest that compound 5 is the active chalcone analogue that contributes to cell death in HepG2 cells via the extrinsic apoptotic pathway. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.10.093

文献信息

• Acrylsäureamide und ihre Verwendung als Fungizide
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0307762A1

  公开（公告）日：1989-03-22

  Die Erfindung betrifft Verbindungen der Formel worin R¹, R², R³, R⁴, R⁵, R⁶ und n die in der Beschreibung angegebenen Bedeutungen besitzen, Verfahren zu deren Herstellung, fungizide Mittel, die diese Verbindungen als Wirkstoffe enthalten, sowie die Verwendung solcher Verbindungen bzw. Mittel zur Bekämpfung von Fungi in der Landwirtschaft und im Gartenbau.

  本发明涉及式如下的化合物 式中 R¹、R²、R³、R⁴、R⁵、R⁶ 和 n 的含义、其制备工艺、含有这些化合物作为活性成分的杀真菌剂，以及这些化合物或制剂在农业和园艺业中防治真菌的用途。
• Synthesis of apoptotic chalcone analogues in HepG2 human hepatocellular carcinoma cells
  作者：Cheon-Soo Park、Yongchel Ahn、Dahae Lee、Sung Won Moon、Ki Hyun Kim、Noriko Yamabe、Gwi Seo Hwang、Hyuk Jai Jang、Heesu Lee、Ki Sung Kang、Jae Wook Lee

  DOI：10.1016/j.bmcl.2015.10.093

  日期：2015.12

  Eight chalcone analogues were prepared and evaluated for their cytotoxic effects in human hepatoma HepG2 cells. Compound 5 had a potent cytotoxic effect. The percentage of apoptotic cells was significantly higher in compound 5-treated cells than in control cells. Exposure to compound 5 for 24 h induced cleavage of caspase-8 and -3, and poly (ADP-ribose) polymerase (PARP). Our findings suggest that compound 5 is the active chalcone analogue that contributes to cell death in HepG2 cells via the extrinsic apoptotic pathway. (C) 2015 Elsevier Ltd. All rights reserved.