(4'-fluorobiphenyl)(4-fluorophenyl)methanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4'-fluorobiphenyl)(4-fluorophenyl)methanone
• 英文别名: 4-fluoro-4'-(4-fluorobenzoyl)biphenyl；4-(4-Fluorophenyl)-4'-fluorobenzophenone；(4-fluorophenyl)-[4-(4-fluorophenyl)phenyl]methanone
• 化学式: C₁₉H₁₂F₂O
• 分子量: 294.3
• InChiKey: UCXGUJKSPQSQDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氟苯硼酸 、 4-溴苯甲酰氯 在 C₂₈H₄₀Br₄N₄Pd₂ 、 potassium carbonate 作用下， 以 乙醇 、 水 为溶剂， 反应 5.0h， 以80%的产率得到(4'-fluorobiphenyl)(4-fluorophenyl)methanone
  参考文献：
  名称：

  Benzimidazole-based palladium–N-heterocyclic carbene: a useful catalyst for C–C cross-coupling reaction at ambient condition

  摘要：

  A convenient way for the synthesis of benzimidazole-based Pd-N-heterocyclic carbene complex and its structural characterization are described. The complex efficiently catalyzes Suzuki cross-coupling reaction in a wide variety of substrates including heteroaromatic system at ambient condition. The catalyst is also effective for multi Suzuki cross-coupling reaction. In addition, the catalyst is equally active toward C-C cross-coupling reaction between acid chloride and arylboronic acid, giving the desired ketones in high yield. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.10.055

文献信息

• A synthesis of biaryl ketones via the C–S bond cleavage of thiol ester by a Cu/Ag salt
  作者：Prasanjit Ghosh、Bhaskar Ganguly、Eliyahu Perl、Sajal Das

  DOI：10.1016/j.tetlet.2017.05.091

  日期：2017.7

  We report the synthesis of biaryl ketones via an unprecedented copper/silver catalyzed acylative cross-coupling of thiol esters with either an arylboronic acid or a potassium aryltrifluoroborate. This new method proceeds without a requisite Pd-catalyst and Cu(I)TC mediator, and is efficient, versatile, operationally simple, and accommodating functionally diverse thiol esters, arylboronic acids, and

  我们报道了通过空前的铜/银催化的硫醇酯与芳基硼酸或芳基三氟硼酸钾的酰基化的交叉偶联反应来合成联芳基酮。此新方法无需必需的Pd催化剂和Cu（I）TC介体即可进行，并且高效，通用，操作简单且可容纳功能多样的硫醇酯，芳基硼酸和芳基三氟硼酸钾。
• High purity diphenyl sulfone, preparation and use thereof for the preparation of a poly(aryletherketone)
  申请人：Louis Chantal

  公开号：US20110201775A1

  公开（公告）日：2011-08-18

  The presence of certain impurities in diphenyl sulfone have a deleterious effect on the properties of the poly(aryletherketone)s produced therein, including one or more of color, melt stability, molecular weight, crystallinity, etc. and here identify those impurities and provide processes for the removal of such impurities.

  二苯砜中存在某些杂质会对生产聚芳醚酮的性能产生不良影响，包括颜色、熔融稳定性、分子量、结晶度等方面。在此，识别这些杂质并提供去除这些杂质的过程。
• Preparation of aryl carbonyl compounds
  申请人：RAYCHEM LIMITED

  公开号：EP0262919B1

  公开（公告）日：1991-09-11
• HIGH PURITY DIPHENYL SULFONE, PREPARATION AND USE THEREOF FOR THE PREPARATION OF A POLY(ARYLETHERKETONE)
  申请人：Solvay Specialty Polymers USA, LLC.

  公开号：EP2342260B1

  公开（公告）日：2014-07-23
• US4898983A
  申请人：——

  公开号：US4898983A

  公开（公告）日：1990-02-06