O-(1-isobutanoyloxyethyl) S-phenyl thiocarbonate

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: O-(1-isobutanoyloxyethyl) S-phenyl thiocarbonate
• 英文别名: O-(1-Isobutanoyloxyethyl) S-Phenyl Thiocarbonate；1-phenylsulfanylcarbonyloxyethyl 2-methylpropanoate
• 化学式: C₁₃H₁₆O₄S
• 分子量: 268.334
• InChiKey: BXLVNRCLFXLJDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  77.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  O-(1-chloroethyl) S-phenyl thiocarbonate 、 异丁酸 在 三乙胺 、 sodium iodide 作用下， 反应 72.0h， 以97%的产率得到O-(1-isobutanoyloxyethyl) S-phenyl thiocarbonate
  参考文献：
  名称：

  [EN] SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF
  [FR] SYNTHESE DE PROMEDICAMENTS A BASE DE CARBAMATE D'ACYLOXYALKYLE ET LEURS INTERMEDIAIRES

  摘要：

  公开号：

  WO2005066122A3

文献信息

• Synthesis of Acyloxyalkyl Carbamate Prodrugs and Intermediates Thereof
  申请人：Gallop Mark A.

  公开号：US20090216037A1

  公开（公告）日：2009-08-27

  Methods for synthesis of 1 -(acyloxy)-alkyl carbamates, particularly, the synthesis of 1 -(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1 -(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

  本文描述了合成1-(酰氧基)-烷基氨基甲酸酯的方法，特别是合成含有一级或二级胺药物的1-(酰氧基)-烷基氨基甲酸酯前药的方法。同时还描述了合成1-(酰氧基)-烷基N-羟基琥珀酰亚胺基碳酸酯的方法，这些中间体在合成1-(酰氧基)-烷基氨基甲酸酯中非常有用。
• Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
  申请人：XenoPort, Inc.

  公开号：US07511158B2

  公开（公告）日：2009-03-31

  Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

  本文描述了合成1-（酰氧）-烷基氨基甲酸酯的方法，特别是合成含有一级或二级胺类药物的1-（酰氧）-烷基氨基甲酸酯前药的方法。还描述了合成1-（酰氧）-烷基N-羟基琥珀酰亚胺碳酸酯的方法，这些中间体在合成1-（酰氧）-烷基氨基甲酸酯中很有用。
• SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF
  申请人：Gallop Mark A.

  公开号：US20120010425A1

  公开（公告）日：2012-01-12

  Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

  本文描述了合成1-(酰氧基)-烷基氨基甲酸酯的方法，特别是合成含有一级或二级胺类药物的1-(酰氧基)-烷基氨基甲酸酯前药的方法。同时，还描述了合成1-(酰氧基)-烷基N-羟基琥珀酰亚胺基碳酸酯的方法，这些中间体在合成1-(酰氧基)-烷基氨基甲酸酯中很有用。
• [EN] SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF<br/>[FR] SYNTHESE DE PROMEDICAMENTS A BASE DE CARBAMATE D'ACYLOXYALKYLE ET LEURS INTERMEDIAIRES
  申请人：XENOPORT INC

  公开号：WO2005066122A3

  公开（公告）日：2005-10-13