4-bromo-2-isopropylbenzo[d]thiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 4-bromo-2-isopropylbenzo[d]thiazole
• 英文别名: 4-Bromo-2-propan-2-yl-1,3-benzothiazole；4-bromo-2-propan-2-yl-1,3-benzothiazole
• 化学式: C₁₀H₁₀BrNS
• 分子量: 256.166
• InChiKey: PTUHVSQCEQVPKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-溴苯并噻唑 、 异丁酸 在 2-吡啶甲酸 、 ferrous(II) sulfate heptahydrate 、 sodium chlorate 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 36.0h， 以43%的产率得到4-bromo-2-isopropylbenzo[d]thiazole
  参考文献：
  名称：

  Ligand-Accelerated Iron Photocatalysis Enabling Decarboxylative Alkylation of Heteroarenes

  摘要：

  A mild, practical protocol for the decarboxylative alkylation of heteroarenes has been accomplished via iron photocatalysis. A diverse range of carboxylic acids readily undergo oxidative decarboxylation and then couple with a broad array of heteroarenes in this transformation. The photoexcited state lifetimes of iron complexes are typically much shorter than those of iridium and ruthenium complexes. Here we describe our effort on iron photocatalysis by utilizing the intramolecular charge transfer pathway of iron-carboxylate complexes.

  DOI：

  10.1021/acs.orglett.9b01439

文献信息

• [EN] DUAL WNT SIGNALING PATHWAY INHIBITORS AND AMPK ACTIVATORS FOR TREATMENTS OF DISEASE<br/>[FR] INHIBITEURS DE LA DOUBLE VOIE DE SIGNALISATION WNT ET ACTIVATEURS D'AMPK DESTINÉS AUX TRAITEMENTS DE MALADIE
  申请人：[en]UNIVERSITY OF MARYLAND, BALTIMORE

  公开号：WO2022256419A1

  公开（公告）日：2022-12-08

  Compounds and compositions are provided as inhibitors of the Wnt/beta-catenin pathway and/or activators of the adenosine monophosphate-activated kinase (AMPK) pathway for the treatment of diseases that implicate the same. Such diseases include cancer o a metabolic disease. Cancers that may be treated by these compounds and compositions include adrenocortical cancer, hepatocellular cancer, hepatoblastoma, malignant melanoma, ovarian cancer, Wilm's tumor, Barrett's esophageal cancer, prostate cancer, colon cancer, colorectal cancer, rectal cancer, pancreatic cancer, bladder cancer, breast cancer (e.g. triple negative breast cancer), gastric cancer, hea & neck cancer, lung cancer, mesothelioma, cervical cancer, uterine cancer, myeloid leukemia cancer, lymphoid leukemia cancer, pilometricoma cancer, medulloblastoma cancer, glioblastoma, and familial adenomatous polyposis. Metabolic diseases include type 2 diabetes, obesity, hyperlipidemia, alcoholic or non-alcoholic fatty liver disease, and liver fibrosis.
• Ligand-Accelerated Iron Photocatalysis Enabling Decarboxylative Alkylation of Heteroarenes
  作者：Zhenlong Li、Xiaofei Wang、Siqi Xia、Jian Jin

  DOI：10.1021/acs.orglett.9b01439

  日期：2019.6.7

  A mild, practical protocol for the decarboxylative alkylation of heteroarenes has been accomplished via iron photocatalysis. A diverse range of carboxylic acids readily undergo oxidative decarboxylation and then couple with a broad array of heteroarenes in this transformation. The photoexcited state lifetimes of iron complexes are typically much shorter than those of iridium and ruthenium complexes. Here we describe our effort on iron photocatalysis by utilizing the intramolecular charge transfer pathway of iron-carboxylate complexes.