4-(N,N-dimethylamino)-2'-carbonitrile-1,1'-biphenyl

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(N,N-dimethylamino)-2'-carbonitrile-1,1'-biphenyl
• 英文别名: 4'-dimethylamino-biphenyl-2-carbonitrile；4'-(Dimethylamino)-1,1'-biphenyl-2-carbonitrile；2-[4-(dimethylamino)phenyl]benzonitrile
• 化学式: C₁₅H₁₄N₂
• 分子量: 222.29
• InChiKey: LJGRGXHTZSFRRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氯-N,N-二甲基苯胺 在 四甲基乙二胺 、 magnesium 、 1,2-二溴乙烷 、 zinc(II) chloride 作用下， 以 四氢呋喃 为溶剂， 反应 0.78h， 生成 4-(N,N-dimethylamino)-2'-carbonitrile-1,1'-biphenyl
  参考文献：
  名称：

  Arylzinc species by microwave assisted Grignard formation–transmetallation sequence: application in the Negishi coupling

  摘要：

  DOI：

  10.1016/j.tet.2005.09.022

文献信息

• [Pd(Cl)2{P(NC5H10)(C6H11)2}2]-A Highly Effective and Extremely Versatile Palladium-Based Negishi Catalyst that Efficiently and Reliably Operates at Low Catalyst Loadings
  作者：Jeanne L. Bolliger、Christian M. Frech

  DOI：10.1002/chem.201001201

  日期：——

  electronically activated, non‐activated, deactivated, sterically hindered, heterocyclic, and functionalized aryl bromides with various (also heterocyclic) arylzinc reagents, typically within a few minutes at 100 °C in the presence of just 0.01 mol % of catalyst. Aryl bromides containing nitro, nitrile, ether, ester, hydroxy, carbonyl, and carboxyl groups, as well as acetals, lactones, amides, anilines,

  [Pd（Cl）2 P（NC 5 H 10）（C 6 H 11）2 } 2 ]（1）已通过使市售的[Pd（cod）（Cl）2 ]反应定量制备。室温下在几分钟内在N 2中与易于制备的1-（二环己基膦酰基）哌啶在甲苯中的环辛二烯）。综合大楼1已被证明是极佳的Negishi催化剂，能够将各种电子活化，非活化，失活，空间受阻，杂环和官能化的芳基溴化物与各种（也是杂环的）芳基锌试剂定量偶联，通常在几分钟内即可完成。 100°C，仅存在0.01 mol％的催化剂。含有硝基，腈，醚，酯，羟基，羰基和羧基的芳基溴化物，以及缩醛，内酯，酰胺，苯胺，烯烃，羧酸，乙酸，吡啶和嘧啶已被成功用作偶联伙伴。此外，在两个反应伙伴中都可以容忍电子和空间变化。实验观察强烈表明分子机制是有效的。
• [EN] AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME<br/>[FR] AGENTS CIBLANT LES AMYLOÏDES ET PROCÉDÉS DE LEUR UTILISATION
  申请人：AMYDIS DIAGNOSTICS

  公开号：WO2015143185A1

  公开（公告）日：2015-09-24

  Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are the methods for treating of diseases associated with an amyloid or amyloid like proteins.

  本文提供了用于检测淀粉样蛋白或类淀粉样蛋白的新型分子转子荧光团的设计和合成。这些荧光团被设计为与淀粉样蛋白或类淀粉样蛋白结合时，与未结合化合物相比表现出增强的荧光发射。本文还披露了用于治疗与淀粉样蛋白或类淀粉样蛋白相关疾病的方法。
• Palladium-Catalyzed Borylation of Phenyl Bromides and Application in One-Pot Suzuki−Miyaura Biphenyl Synthesis
  作者：Pierre-Emmanuel Broutin、Igor Čerňa、Maria Campaniello、Frédéric Leroux、Françoise Colobert

  DOI：10.1021/ol048303b

  日期：2004.11.1

  reaction of pinacolborane with various aryl bromides in the presence of a catalytic amount of Pd(OAc)(2) together with DPEphos as ligand and Et(3)N as base provided arylboronates. High yields were obtained in the case of electron-donor substituted aryl bromides. The direct preparation of arylboronates allowed the one-pot, two-step synthesis of unsymmetrical biaryls in high yields. [reaction: see text]

  在催化量的Pd（OAc）（2）与DPEphos作为配体和Et（3）N作为碱的存在下，频哪醇硼烷与各种芳基溴的偶联反应提供了芳基硼酸酯。在电子给体取代的芳基溴化物的情况下，获得了高收率。直接制备芳基硼酸酯允许高产率地一锅两步合成不对称联芳基。[反应：看文字]
• [EN] METHODS OF DETECTING NEUROLOGICAL DISORDERS VIA BINDING TO PHOSPHORYLATED TAU PROTEIN<br/>[FR] MÉTHODES DE DÉTECTION DE TROUBLES NEUROLOGIQUES PAR LIAISON À UNE PROTÉINE TAU PHOSPHORYLÉE
  申请人：SARRAF STELLA

  公开号：WO2021055639A1

  公开（公告）日：2021-03-25

  Provided herein are methods and compositions for determining whether a patient suffers from a neurological disease or disorder is provided, comprising detecting the presence of a phosphorylated tau protein in a tissue of the patient, wherein the detecting comprises contacting the phosphorylated tau protein with a compound described herein.

  本文提供了一种确定患者是否患有神经系统疾病或紊乱的方法和组合物，包括检测患者组织中磷酸化tau蛋白的存在，其中检测包括将磷酸化tau蛋白与本文描述的化合物接触。
• COMPOSITIONS AND METHODS FOR DETECTION OF TRAUMATIC BRAIN INJURY
  申请人：Amydis, Inc.

  公开号：US20210369873A1

  公开（公告）日：2021-12-02

  The present disclosure relates generally to compositions and methods for determining whether a patient suffers from a traumatic brain injury (TBI) by detecting the presence of an amyloid beta protein in an eye of the patient. Also provided are compositions and methods for preparing a patient for diagnosis and treatment of traumatic brain injury (TB).

  本公开涉及一般用于确定患者是否患有创伤性脑损伤（TBI）的组合物和方法，通过检测患者眼睛中淀粉样蛋白的存在。还提供了用于为创伤性脑损伤（TBI）的诊断和治疗准备患者的组合物和方法。