N-Chloro-N-ethylaniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Chloro-N-ethylaniline
• 化学式: C₈H₁₀ClN
• 分子量: 155.627
• InChiKey: WGLTVKFTYJLAEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-乙基苯胺 在 sodium hypochlorite 作用下， 以 水 为溶剂， 生成 N-Chloro-N-ethylaniline
  参考文献：
  名称：

  Incompleteness of Wastewater Dechlorination

  摘要：

  Dechlorination by sulfur dioxide or other S(IV) compounds is employed to protect aquatic wildlife from toxic residual chlorine in wastewater treatment plant effluents. Tests at two wastewater treatment plants show that dechlorination removes 87-98% of residual chlorine but that a remainder, which exceeds regulatory limits, is very slowly reduced. Judging from kinetic evidence, chlorinated secondary organic amines and peptides probably contribute to S(IV)-resistant residual chlorine. Most of the S(IV)-resistant fraction is extractable into octanol. Its hydrophobic character suggests that this fraction may be harmful to organisms in receiving streams. S(IV)-resistant residual chlorine has been overlooked previously because the dechlorinating agent interferes with standard analytical methods for total chlorine.

  DOI：

  10.1021/es00004a023

文献信息

• [EN] NOVEL HDMX INHIBITORS AND THEIR USE FOR CANCER TREATMENT<br/>[FR] NOUVEAUX INHIBITEURS HDMX ET LEUR UTILISATION DANS LE TRAITEMENT DU CANCER
  申请人：MIRX PHARMACEUTICALS LLC

  公开号：WO2015153535A1

  公开（公告）日：2015-10-08

  The present invention provides for novel acridine-like class of compounds that have demonstrated efficiency in treating cancer. The compounds of the present invention have demonstrated efficacy in binding to and antagonizing the activity of the p53 repressor, HDMX. Once administered to a cell, the compounds of the present invention bind HDMX, thereby allowing p53 to induce apoptosis of the cancerous cell. A combination of this class of compounds along with Nutlin3 provides a novel approach to treat cancers.

  本发明提供了一种新型的类似于吖啶的化合物，已经证明可以有效地治疗癌症。本发明的化合物已经证明在结合并拮抗p53抑制剂HDMX的活性方面具有疗效。一旦这些化合物被注入细胞，它们会与HDMX结合，从而使p53诱导癌细胞凋亡。将这类化合物与Nutlin3结合使用可以提供一种治疗癌症的新方法。
• [EN] PROCESS FOR THE DIASTEREOISOMERIC RESOLUTION OF 5-METHYLTETRAHYDROFOLIC ACID<br/>[FR] PROCÉDÉ DE RÉSOLUTION DIASTÉRÉOISOMÉRIQUE D'ACIDE 5-MÉTHYLTÉTRAHYDROFOLIQUE
  申请人：GNOSIS SPA

  公开号：WO2009103333A1

  公开（公告）日：2009-08-27

  The invention relates to a process for the diastereoisomeric resolution of 5-methyltetrahydrofolic acid; it discloses also a crystalline amine salt of 5-methyltetrahydrofolic acid and is further directed to a process for the transformation of the single diastereoisomers of the 5-methyltetrahydrofolic amine salts obtained by the process of the invention into the corresponding free acid or into an alkaline earth metal salt. The invention provides a simple, economically advantageous and efficient process and allows to obtain stable and pure (6R) and ( 6S) -diastereoisomers of 5-methyltetrahydrofolic acid in a good yield and diastereoisomeric purity.

  本发明涉及一种对5-甲基四氢叶酸进行对映异构体分离的方法；还揭示了5-甲基四氢叶酸的晶态胺盐，并进一步针对本发明所得的5-甲基四氢叶酸胺盐的单一对映异构体进行转化成相应的游离酸或碱土金属盐的方法。本发明提供了一种简单、经济优势和高效的方法，并允许以良好的产率和对映异构体纯度获得稳定和纯净的(6R)和(6S)-5-甲基四氢叶酸对映异构体。
• Disazo compounds and use thereof as fiber reactive dyes
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0609832A1

  公开（公告）日：1994-08-10

  A bisazo compound of the following formula: wherein R¹ and R³ are each hydrogen or alkyl; D is phenylene or naphthylene; one of X¹ and X² is NH₂ and the other is OH; Z¹ and Z² are each -CH=CH₂ or -CH=CH₂Z' in which Z' is a splittable group; B is monosulfophenylene, monosulfophenylene-methylene or mono- or disulfonaphthylene-methylene; U is phenylene or an aliphatic bridging group; and J is an amono-derivative group or, J may be alkoxy when X¹ is OH and U is phenylene, and J may be alkoxy or phenoxy when X¹ is OH and U is the aliphatic bridging group. This compound is useful for dyeing or printing fiber materials and gives a dyed or printed product having a color superior in various fastness properties with superior build-up property.

  下式所示的双偶氮化合物： 其中 R¹ 和 R³ 分别为氢或烷基；D 为亚苯基或萘基；X¹ 和 X² 中的一个为 NH₂，另一个为 OH；Z¹ 和 Z² 分别为 -CH=CH₂ 或 -CH=CH₂Z'，其中 Z' 为可拆分基团；B 为单亚磺酰亚苯基、单亚磺酰亚苯基或单亚磺酰亚苯基或二亚磺酰亚萘基；U 是亚苯基或脂肪族桥基；J 是氨基衍生物基团，或者，当 X¹ 是 OH 和 U 是亚苯基时，J 可以是烷氧基；当 X¹ 是 OH 和 U 是脂肪族桥基时，J 可以是烷氧基或苯氧基。这种化合物可用于纤维材料的染色或印花，染色或印花后的产品在各种牢度性能方面都具有优异的色彩和上色性能。
• Monoazo compounds and method for dyeing or printing fiber materials using the same
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0719840A1

  公开（公告）日：1996-07-03

  A monoazo compound of the formula (I): wherein D represents a phenyl or naphthyl group; A represents a group of the formula: in which R1 represents a methyl group etc., R2 represents a hydroxyl group or an amino group, R3 represents a hydrogen atom, etc.; or A represents a group of the formula: in which W represents an alkylene group, R4 represents a lower alkyl group, R5 represents a hydrogen atom, a halogen atom, etc.;    R6 and R7 represent a hydrogen atom or a straight chain or branched chain alkyl group    R8 and R9 represent a hydrogen atom, an alkyl group, a cycloalkyl group, a phenyl group or a naphthyl group; n is 2, 3 or 4; Y represents -CH=CH2 or -CH2CH2Z in which Z represents a group removable by the action of an alkali; or a salt thereof, is suitable for dyeing or printing materials having a hydroxy group and/or an amide group.

  式 (I) 的单偶氮化合物： 其中 D 代表苯基或萘基； A 代表式中的一个基团 其中 R1 代表甲基等，R2 代表羟基或氨基，R3 代表氢原子等； 或 A 代表式中的一个基团： 其中 W 代表亚烷基，R4 代表低级烷基，R5 代表氢原子、卤素原子等； R6 和 R7 代表氢原子或直链或支链烷基 R8 和 R9 代表氢原子、烷基、环烷基、苯基或萘基； n 是 2、3 或 4； Y 代表 -CH=CH2 或 -CH2CH2Z，其中 Z 代表在碱作用下可去除的基团； 或其盐，适用于具有羟基和/或酰胺基的染色或印花材料。
• Polybutene-1 resin composition and a method of accelerating the crystal transformation
  申请人：NEW JAPAN CHEMICAL CO.,LTD.

  公开号：EP0776933A1

  公开（公告）日：1997-06-04

  Disclosed are a polybutene-1 resin composition comprising a polybutene-1 resin and a Form-II to Form-I crystal transformation accelerator, and a method of accelerating the Form-II to Form-I crystal transformation comprising molding the polybutene-1 resin composition and allowing the molded product to stand at about 0 to 50 °C, the crystal transformation accelerator being an amide compound.

  本发明公开了一种聚丁烯-1 树脂组合物，该组合物由聚丁烯-1 树脂和一种从 Form-II 到 Form-I 的晶体转变促进剂组成；以及一种加速从 Form-II 到 Form-I 晶体转变的方法，该方法包括模塑聚丁烯-1 树脂组合物，并使模塑产品在约 0 至 50 °C 下静置，晶体转变促进剂是一种酰胺化合物。