(2β,6β)-2-(4-hydroxyphenyl)-6-phenylspiro[cyclohexane-1,2'-indene]-1',3',4-trione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2β,6β)-2-(4-hydroxyphenyl)-6-phenylspiro[cyclohexane-1,2'-indene]-1',3',4-trione
• 英文别名: (3R,5S)-3-(4-hydroxyphenyl)-5-phenylspiro[cyclohexane-4,2'-indene]-1,1',3'-trione
• 化学式: C₂₆H₂₀O₄
• 分子量: 396.442
• InChiKey: OCHOMQQWDNRBLY-XZOQPEGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,3-茚满二酮 、 对羟基苯甲醛 、 苄叉丙酮 在 (L)-5,5-dimethylthiazolidinium-4-carboxylate 作用下， 以 甲醇 为溶剂， 反应 73.0h， 以51%的产率得到(2β,6β)-2-(4-hydroxyphenyl)-6-phenylspiro[cyclohexane-1,2'-indene]-1',3',4-trione
  参考文献：
  名称：

  Identification of Biphenyl-Based Hybrid Molecules Able To Decrease the Intracellular Level of Bcl-2 Protein in Bcl-2 Overexpressing Leukemia Cells

  摘要：

  With the aim of enhancing the structural complexity and diversity of an existing collection of bi- and terphenyl compounds, we synthesized hybrid molecules comprising of spirocyclic ketones (a complexity-bearing core) and bi/terphenyls (privileged fragments). Compounds 1, 3, 4, and 6 showed well-defined activity on apoptosis and differentiation, making them potential leads for development as new anticancer agents and chemical probes to study signaling networks in neoplastic cells.

  DOI：

  10.1021/jm900907s

文献信息

• Identification of Biphenyl-Based Hybrid Molecules Able To Decrease the Intracellular Level of Bcl-2 Protein in Bcl-2 Overexpressing Leukemia Cells
  作者：Daniela Pizzirani、Marinella Roberti、Stefania Grimaudo、Antonietta Di Cristina、Rosaria Maria Pipitone、Manlio Tolomeo、Maurizio Recanatini

  DOI：10.1021/jm900907s

  日期：2009.11.12

  With the aim of enhancing the structural complexity and diversity of an existing collection of bi- and terphenyl compounds, we synthesized hybrid molecules comprising of spirocyclic ketones (a complexity-bearing core) and bi/terphenyls (privileged fragments). Compounds 1, 3, 4, and 6 showed well-defined activity on apoptosis and differentiation, making them potential leads for development as new anticancer agents and chemical probes to study signaling networks in neoplastic cells.