卡匹帕明顺丁烯二酸盐 | 100482-23-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 中文名称: 卡匹帕明顺丁烯二酸盐
• 中文别名: 马来酸卡匹帕明
• 英文名称: Carpipramine maleate
• 英文别名: (Z)-but-2-enedioic acid;1-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-piperidin-1-ylpiperidine-4-carboxamide
• CAS: 100482-23-3
• 化学式: C32H42N4O5
• 分子量: 562.7
• InChiKey: LQMNVYGQJJRMRR-BTJKTKAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.67
• 重原子数：
  41
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  136
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• METHOD FOR PRODUCING PATCH, AND PATCH
  申请人：Hashimoto Eiji

  公开号：US20140037710A1

  公开（公告）日：2014-02-06

  A method for producing a patch including a support layer and an adhesive layer, comprising the step of forming the adhesive layer with use of an adhesive layer composition obtained by mixing an alkali metal diacetate, a drug, and a nonaqueous adhesive base such that the molar ratio between the drug and the alkali metal diacetate (the number of moles of the drug:the number of moles of the alkali metal diacetate) is from 1:0.5 to 1:15.

  一种生产贴片的方法，包括形成支撑层和粘合层，其中粘合层的制备步骤是使用粘合层组合物通过混合一种碱金属二乙酸盐、一种药物和一种非水粘合基材料形成，使得药物和碱金属二乙酸盐的摩尔比（药物的摩尔数：碱金属二乙酸盐的摩尔数）在1:0.5到1:15之间。
• SUSTAINED-RELEASE MICROSPHERE CONTAINING ANTIPSYCHOTIC AND PROCESS FOR PRODUCING THE SAME
  申请人：YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.

  公开号：EP0669128A1

  公开（公告）日：1995-08-30

  A sustained-release microsphere produced by enclosing a hydrophobic antipsychotic such as bromperidol or haloperidol in a base comprising a biocompatible polymer such as polylactic acid or a lactic acid/glycolic acid copolymer. It can exhibit a desired pharmacological effect, where a long-term administration is necessary, by injecting once every 1 to 8 weeks instead of every day. As a result, a remarkable improvement can be expected in the compliance during maintenance therapy. In addition, the use of the biocompatible polymer serves to entirely dispense with surgical operations such as implantation, facilitates hypodermic and intramuscular injection just like the case of suspending injection, and can dispense with the widrawal of the microsphere. Furthermore, the microsphere can be administered with little aversion and pain.

  一种缓释微球，将溴哌利多或氟哌啶醇等疏水性抗精神病药物包裹在由聚乳酸或乳酸/乙醇酸共聚物等生物相容性聚合物组成的基质中。在需要长期用药的情况下，只需每 1 至 8 周注射一次，而不是每天注射一次，就能发挥理想的药理作用。因此，可望显著改善维持治疗期间的依从性。此外，使用生物相容性聚合物可以完全省去植入等外科手术，方便皮下注射和肌肉注射，就像悬浮注射一样，还可以省去微球的拉伸。此外，施用微球时几乎不会产生厌恶感和疼痛感。
• Systems and methods for delivery of materials
  申请人：Landec Corporation

  公开号：EP2502619A2

  公开（公告）日：2012-09-26

  A release composition for agricultural applications which comprises an ECC polymer and a release material associated with the ECC polymer, wherein the release material is a fertilizer, biocide, insecticide or fungicide, and wherein the ECC polymer is defined as a polymer (A) which comprises polymeric molecules having a backbone and comprising at least one moiety which has the formula -b-Cy, wherein the -b-Cy moiety either (a) forms part of a repeating unit of the backbone, the repeating unit having the formula (1) below where Ych is a moiety forming part of the backbone, b is a bond or moiety which links the Cy moiety to Ych, and Cy is a moiety which is associated with other moieties to provide the ECC polymer with crystallinity, or (b) forms part of a terminal unit of the backbone, the terminal unit having the formula (2) below          -Yterm- b-Cy     (2) where Yterm is a moiety at the end of the backbone, and b and Cy are as defined in formula (1); (B) in which at least 50% by weight of the Cy moieties are present in terminal units of formula (2); and (C) which has a crystalline melting temperature, Tp, of at least 0°C and a ΔH of at least 3J/g which results from association of the Cy moieties.

  一种用于农业应用的释放组合物，它包括 ECC 聚合物和与 ECC 聚合物相关的释放材料、 其中释放材料为肥料、杀菌剂、杀虫剂或杀真菌剂，ECC 聚合物定义为聚合物 (A) 由具有骨架的聚合物分子组成，至少包含一个分子式为-b-Cy 的分子，其中-b-Cy 分子可以是 (a) 构成骨架重复单元的一部分，该重复单元具有下式(1) 其中 Ych 是构成骨架一部分的分子，b 是连接 Cy 分子和 Ych 的键或分子，Cy 是与其他分子相连的分子，使 ECC 聚合物具有结晶性、 或 (b) 构成骨架末端单元的一部分，末端单元具有下式 (2) -Yterm- b-Cy (2) 其中 Yterm 是位于骨架末端的分子，b 和 Cy 如式（1）中所定义； (B) 其中至少 50%（按重量计）的 Cy 分子存在于式（2）的末端单元中；以及 (C) 其结晶熔化温度 Tp 至少为 0℃，Cy 分子结合产生的 ΔH 至少为 3J/g。
• Delivery of drugs
  申请人：Landec Corporation

  公开号：EP2500015A1

  公开（公告）日：2012-09-19

  Formulations of drugs and crystalline side chain polymers to provide controlled and/or sustained release drug formulations.

  药物和结晶侧链聚合物的配方，以提供控释和/或缓释药物制剂。
• METHOD FOR PRODUCING ADHESIVE PATCH, AND ADHESIVE PATCH
  申请人：Hisamitsu Pharmaceutical Co., Inc.

  公开号：EP2700401A1

  公开（公告）日：2014-02-26

  A method for producing a patch including a support layer and an adhesive layer, comprising the step of forming the adhesive layer with use of an adhesive layer composition obtained by mixing an alkali metal diacetate, a drug, and a nonaqueous adhesive base such that the molar ratio between the drug and the alkali metal diacetate (the number of moles of the drug : the number of moles of the alkali metal diacetate) is from 1:0.5 to 1:15.

  一种生产包括支撑层和粘合剂层的贴片的方法，包括以下步骤：使用通过混合碱金属二乙酸酯、药物和非水粘合剂基质得到的粘合剂层组合物形成粘合剂层，使药物和碱金属二乙酸酯之间的摩尔比（药物的摩尔数：碱金属二乙酸酯的摩尔数）为 1:0.5 至 1:15。