α-p-toluenesulfonyl methyl mercaptan

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-p-toluenesulfonyl methyl mercaptan
• 英文别名: (4-Methylphenyl)sulfonylmethanethiol
• 化学式: C₈H₁₀O₂S₂
• 分子量: 202.298
• InChiKey: PHDOOQJOZBOWEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  43.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  α-p-toluenesulfonyl methyl mercaptan 在 silica gel 作用下， 以 light petroleum 为溶剂， 以83%的产率得到C₉H₁₂O₂S₃
  参考文献：
  名称：

  Vault Isomerization and its Application to the Synthesis of a Dideoxydysoxysulfone Precursor

  摘要：

  新型二氧化硅诱导的α-巯基砜受控歧化反应生成了α-巯基α′-磺酰基硫化物。作为一种新工艺--拱顶异构化--的核心，它的发现和利用允许对之前描述的合成前体进行更有效的合成。

  DOI：

  10.1071/ch08051
• 作为产物：
  描述：

  α-tosyl dimethyldisulfide 在 吡啶 、 苯硫酚 、 silica gel 作用下， 以 二氯甲烷 、 氯仿 为溶剂， 生成 C₉H₁₂O₂S₃ 、 α-p-toluenesulfonyl methyl mercaptan
  参考文献：
  名称：

  Vault Isomerization and its Application to the Synthesis of a Dideoxydysoxysulfone Precursor

  摘要：

  新型二氧化硅诱导的α-巯基砜受控歧化反应生成了α-巯基α′-磺酰基硫化物。作为一种新工艺--拱顶异构化--的核心，它的发现和利用允许对之前描述的合成前体进行更有效的合成。

  DOI：

  10.1071/ch08051

文献信息

• Sulfur containing compounds
  申请人：——

  公开号：US20030220524A1

  公开（公告）日：2003-11-27

  This invention is directed to novel and known stufur containing compounds and pharmaceutically acceptable salts thereof that have utility as antifungals and as antiproliferative agents against mammalian cells, in particular cancer cells and most particularly leukemia-derived cells. The invention provides a method for synthesizing certain of the sulfur containing compounds that is more efficient than previously known methods.

  这项发明涉及新颖且已知的含有硫的化合物以及具有抗真菌活性和作为哺乳动物细胞，特别是癌细胞，尤其是白血病来源细胞的抗增殖剂的药用可接受盐。发明提供了一种合成某些含硫化合物的方法，该方法比先前已知的方法更有效。
• A New Synthesis for Antifungal α-Sulfone Disulfides
  作者：Richard Francis Langler、Robert Antle McNamara、Paul Eric O'Connor、Stephanie Lee MacQuarrie

  DOI：10.1071/ch99086

  日期：——

  An α-ester disulfide is shown to be a useful precursor for the preparation of several α-sulfone disulfides. These new α-sulfone disulfides are all fungitoxic against Aspergillus niger and Aspergillus flavus. RSO2CH2SSCH9

  研究表明，α-酯二硫化物是制备多种α-砜二硫化物的有用前体。 是制备多种 α-砜二硫化物的有用前体。这些新的α-砜 二硫化物都对黑曲霉和黄曲霉具有真菌毒性。 和黄曲霉的真菌毒性。 RSO2CH2SSCH9
• SULFUR CONTAINING COMPOUNDS
  申请人：University Health Network

  公开号：EP1259482A2

  公开（公告）日：2002-11-27
• INHIBITION OF FcyR-MEDIATED PHAGOCYTOSIS WITH REDUCED IMMUNOGLOBULIN PREPARATIONS
  申请人：Branch Donald R.

  公开号：US20100047249A1

  公开（公告）日：2010-02-25

  The invention relates to pharmaceutical compositions for inhibiting FcγR-mediated phagocytosis comprising a reduced immunoglobulin inhibitor of FcγR-mediated phagocytosis, such as anti-D, in combination with a pharmaceutically acceptable carrier. The invention also relates to methods for treating or preventing an autoimmune or alloimmune disease comprising administering to a subject in need thereof a therapeutically effective amount of a reduced immunoglobulin inhibitor of FcγR-mediated phagocytosis.
• [EN] SULFUR CONTAINING COMPOUNDS<br/>[FR] COMPOSÉS CONTENANT DU SOUFRE
  申请人：UNIV HEALTH NETWORK

  公开号：WO2001062668A2

  公开（公告）日：2001-08-30

  This invention is directed to novel and known sulfur containing compounds and pharmaceutically acceptable salts thereof that have utility as antifungals and as antiproliferative agents against mammalian cells, in particular cancer cells and most particularly leukemia-derived cells. The invention provides a method for synthesizing certain of the sulfur containing compounds that is more efficient than previously known methods.