2-(2-bromophenyl)-N-(4-methylphenyl)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-bromophenyl)-N-(4-methylphenyl)acetamide
• 英文别名: (2-bromo-phenyl)-acetic acid p-toluidide；(2-Brom-phenyl)-essigsaeure-p-toluidid
• 化学式: C₁₅H₁₄BrNO
• 分子量: 304.186
• InChiKey: BYQYHGMABAGJMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(2-bromophenyl)-N-(4-methylphenyl)acetamide 在 potassium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以84%的产率得到2-(2-bromophenyl)-2-hydroxy-N-(p-tolyl)acetamide
  参考文献：
  名称：

  一种α-羟基酰胺类化合物的合成方法

  摘要：

  本发明提供了一种α-羟基酰胺类化合物的合成方法,具体包括以下步骤：（1）将酰胺、碱以及二甲基亚砜混合，在空气气氛中密封，反应;（2）反应结束后，冷却到室温，加入饱和食盐水洗涤，用乙酸乙酯萃取3-5次，合并有机层，无水硫酸钠干燥，减压浓缩，得粗产物;（3）粗产物经柱色谱分离提纯，即得所需的α-羟基酰胺类化合物。跟现有技术相比，本发明在氢氧化钾/二甲基亚砜这一简单体系中进行，避免使用复杂或昂贵的催化剂；原料易制备；温度适当，操作易控制；利用空气为绿色氧化剂一步直接得到目标产物；反应高效，产率高达98%，有利工业化生产。

  公开号：

  CN103755584B
• 作为产物：
  描述：

  邻溴氰苄 在 氢氧化钾 作用下， 生成 2-(2-bromophenyl)-N-(4-methylphenyl)acetamide
  参考文献：
  名称：

  Iodine deficiency in Calabria: Characterization of endemic goiter and analysis of different indicators of iodine status region-wide

  摘要：

  The distribution of goiter prevalence in schoolchildren (no.=13,984, age 6-14 yr), the neonatal TSH results obtained from the congenital hypothyroidism screening program and the urinary iodine excretion values (no.=284) were employed for the assessment of iodine deficiency in Calabria, a Southern Italy region. Data were collected during the years 1990-1996. In the inland territory, goiter prevalence ranged from 19 to 64%. At sea level, there was a great variability of goiter prevalence, with values varying from 5.3 to 25.7%. The analysis of the neonatal hypothyroidism screening program data (no.=21,078) showed a 14.8% frequency of TSH levels >5 muU/ml whole blood in newborns from the inland territory and a 14.1% frequency at sea level. Urinary iodine excretion resulted (mean+/-SD) 53.8+/-43.4 mug/l (range: <20 to 189 mu g/1) in the inland territory and 89.6+/-59.8 mu g/l (range: 26 to 333 mu g/l) at sea level. Median urinary iodine excretion values in 13 villages or small towns of the inland territory ranged from 31 to 57 mu g/l. In 2 major towns located at sea level, the median iodine excretion values were 72 mu g/l in Crotone main city and 94 mu g/l in Reggio Calabria main city. The data indicated that moderate, with pockets of severe iodine deficiency is present in the inland region while iodine supply varies from sufficient to marginally low in the coastal areas. Mild iodine deficiency was found in a major town located at sea level.

  DOI：

  10.1007/bf03343991

文献信息

• Copper-catalyzed tandem oxidative cyclization of arylacetamides: efficient access to N-functionalized isatins
  作者：Jie Sun、Bingxin Liu、Bin Xu

  DOI：10.1039/c3ra40657a

  日期：——

  An efficient copper-catalyzed synthesis of N-substituted isatins has been developed in good yields from easily accessible arylacetamides. A wide range of electronically and structurally varied nitrogen fragments could be assembled through this tandem C–O/C–N bond-forming process by tuning the reaction conditions.

  已经开发出一种高效的铜催化合成N-取代异烟酸的反应，能够从易于获得的芳基乙酰胺中以良好的产率合成。通过调整反应条件，可以组装多种电子和结构各异的氮基片段，采用这种串联C–O/C–N键形成的过程。
• 一种α-羟基酰胺类化合物的合成方法
  申请人：安徽师范大学

  公开号：CN103755584B

  公开（公告）日：2016-02-17

  本发明提供了一种α-羟基酰胺类化合物的合成方法,具体包括以下步骤：（1）将酰胺、碱以及二甲基亚砜混合，在空气气氛中密封，反应;（2）反应结束后，冷却到室温，加入饱和食盐水洗涤，用乙酸乙酯萃取3-5次，合并有机层，无水硫酸钠干燥，减压浓缩，得粗产物;（3）粗产物经柱色谱分离提纯，即得所需的α-羟基酰胺类化合物。跟现有技术相比，本发明在氢氧化钾/二甲基亚砜这一简单体系中进行，避免使用复杂或昂贵的催化剂；原料易制备；温度适当，操作易控制；利用空气为绿色氧化剂一步直接得到目标产物；反应高效，产率高达98%，有利工业化生产。
• Iodine deficiency in Calabria: Characterization of endemic goiter and analysis of different indicators of iodine status region-wide
  作者：G. Costante、L. Grasso、E. Schifino、M. F. Marasco、U. Crocetti、C. Capula、R. Chiarella、O. Ludovico、M. Nocera、G. Parlato、S. Filetti

  DOI：10.1007/bf03343991

  日期：2002.3

  The distribution of goiter prevalence in schoolchildren (no.=13,984, age 6-14 yr), the neonatal TSH results obtained from the congenital hypothyroidism screening program and the urinary iodine excretion values (no.=284) were employed for the assessment of iodine deficiency in Calabria, a Southern Italy region. Data were collected during the years 1990-1996. In the inland territory, goiter prevalence ranged from 19 to 64%. At sea level, there was a great variability of goiter prevalence, with values varying from 5.3 to 25.7%. The analysis of the neonatal hypothyroidism screening program data (no.=21,078) showed a 14.8% frequency of TSH levels >5 muU/ml whole blood in newborns from the inland territory and a 14.1% frequency at sea level. Urinary iodine excretion resulted (mean+/-SD) 53.8+/-43.4 mug/l (range: <20 to 189 mu g/1) in the inland territory and 89.6+/-59.8 mu g/l (range: 26 to 333 mu g/l) at sea level. Median urinary iodine excretion values in 13 villages or small towns of the inland territory ranged from 31 to 57 mu g/l. In 2 major towns located at sea level, the median iodine excretion values were 72 mu g/l in Crotone main city and 94 mu g/l in Reggio Calabria main city. The data indicated that moderate, with pockets of severe iodine deficiency is present in the inland region while iodine supply varies from sufficient to marginally low in the coastal areas. Mild iodine deficiency was found in a major town located at sea level.