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3-(3,4-dichlorophenyl)butyramide

中文名称
——
中文别名
——
英文名称
3-(3,4-dichlorophenyl)butyramide
英文别名
3-(3,4-Dichlorophenyl)butanamide
3-(3,4-dichlorophenyl)butyramide化学式
CAS
——
化学式
C10H11Cl2NO
mdl
——
分子量
232.109
InChiKey
RXLBUNTXXRHMSF-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.6
  • 重原子数:
    14
  • 可旋转键数:
    3
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.3
  • 拓扑面积:
    43.1
  • 氢给体数:
    1
  • 氢受体数:
    1

反应信息

  • 作为产物:
    参考文献:
    名称:
    α,β-不饱和酰胺的超酸活化及其亲电反应
    摘要:
    已经研究了用三氟甲磺酸 (CF3SO3H) 或过量 AlCl3 引发的 α,β-不饱和酰胺对弱亲核试剂如芳烃和环己烷的亲电反应性。在 AlCl3 存在下,酰胺通常很容易与芳烃缩合,以极好的收率得到 3-芳基丙酰胺和相关化合物,而一些酰胺也可以与环己烷进行选择性离子氢化,得到饱和酰胺。这些反应的拟议机制涉及双阳离子中间体(超亲电试剂)。报告了对双阳离子物质的直接观察(通过低温 NMR)。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
    DOI:
    10.1002/ejoc.200400313
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文献信息

  • NOVEL COMPOUNDS ADVANTAGEOUS IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
    申请人:Pesyan Amir
    公开号:US20110046128A1
    公开(公告)日:2011-02-24
    A series of novel compounds showing anticonvulsant, chemical countermeasure(s), and analgesic activities is described. Such pharmaceutically active compounds may also show utility in the treatment of other central nervous system (“CNS”) diseases and disorders, such as anxiety, depression, insomnia, migraine headaches, schizophrenia, Parkinson's disease, spasticity, Alzheimer's disease, and bipolar disorder. Furthermore, such compounds may additionally find utility as analgesics (e.g., for the treatment of chronic or neuropathic pain) and as neuroprotective agents useful in the treatment of stroke(s), chronic neurodegenerative diseases (such as Alzheimer's disease and Huntington's disease), and/or traumatic brain and/or spinal cord injuries. Moreover, these/such compounds may also be useful in the treatment of status epilepticus and/or as chemical countermeasures.
    本文介绍了一系列新型化合物,具有抗惊厥、化学对抗剂和镇痛活性。这些药物活性化合物也可能在治疗其他中枢神经系统(“CNS”)疾病和障碍方面发挥作用,如焦虑、抑郁、失眠、偏头痛、精神分裂症、帕金森病、痉挛、阿尔茨海默病和双相情感障碍。此外,这些化合物还可以作为镇痛剂(例如,用于慢性或神经性疼痛的治疗)和作为神经保护剂,有助于治疗中风、慢性神经退行性疾病(如阿尔茨海默病和亨廷顿病)以及创伤性脑和/或脊髓损伤。此外,这些化合物还可以用于治疗癫痫持续状态和/或作为化学对抗剂。
  • Compounds advantageous in the treatment of central nervous system diseases and disorders
    申请人:AurimMed Pharma, Inc.
    公开号:US10793515B2
    公开(公告)日:2020-10-06
    A series of novel amides showing broad pharmaceutical activity. Compounds described herein are effective as anticonvulsants, chemical countermeasures, and analgesics. Such compounds also show, neuroprotective/neuroreparative effects and activity against spinal muscular atrophy. Such pharmaceutically active compounds show utility in the treatment of central nervous system (“CNS”) diseases and disorders, such as anxiety, depression, insomnia, migraine headaches, schizophrenia, neurodegenerative diseases (e.g., Parkinson's disease, Alzheimer's, ALS, and Huntington's disease) spasticity, and bipolar disorder. Furthermore, such compounds may additionally find utility as analgesics (e.g., for the treatment of chronic or neuropathic pain) and as neuroprotective agents useful in the treatment of stroke(s), and/or traumatic brain and/or spinal cord injuries.
    一系列新型酰胺具有广泛的药物活性。本文所述化合物可作为抗惊厥剂、化学对策和镇痛剂。这些化合物还具有神经保护/神经恢复作用,并对脊髓性肌肉萎缩具有活性。这类药物活性化合物可用于治疗中枢神经系统(CNS)疾病和失调,如焦虑症、抑郁症、失眠症、偏头痛、精神分裂症、神经退行性疾病(如帕金森氏病、阿尔茨海默氏症、渐冻人症和亨廷顿氏病)、痉挛症和躁狂症。此外,这类化合物还可作为镇痛剂(如治疗慢性疼痛或神经性疼痛)和神经保护剂用于治疗中风和/或创伤性脑损伤和/或脊髓损伤。
  • US9212155B2
    申请人:——
    公开号:US9212155B2
    公开(公告)日:2015-12-15
  • [EN] NOVEL COMPOUNDS ADVANTAGEOUS IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS<br/>[FR] NOUVEAUX COMPOSÉS BÉNÉFIQUES DANS LE TRAITEMENT DE MALADIES ET DE TROUBLES DU SYSTÈME NERVEUX CENTRAL
    申请人:AURIMED PHARMA INC
    公开号:WO2011034849A1
    公开(公告)日:2011-03-24
    A series of novel compounds showing anticonvulsant, chemical countermeasure(s), and analgesic activities is described. Such pharmaceutically active compounds may also show utility in the treatment of other central nervous system ("CNS") diseases and disorders, such as anxiety, depression, insomnia, migraine headaches, schizophrenia, Parkinson's disease, spasticity, Alzheimer's disease, and bipolar disorder. Furthermore, such compounds may additionally find utility as analgesics (e.g., for the treatment of chronic or neuropathic pain) and as neuroprotective agents useful in the treatment of stroke(s), chronic neurodegenerative diseases (such as Alzheimer's disease and Huntington's disease), and/or traumatic brain and/or spinal cord injuries. Moreover, these/such compounds may also be useful in the treatment of status epilepticus and/or as chemical countermeasures.
  • Superacidic Activation ofα,β-Unsaturated Amides and Their Electrophilic Reactions
    作者:Konstantin Yu. Koltunov、Stéphane Walspurger、Jean Sommer
    DOI:10.1002/ejoc.200400313
    日期:2004.10
    The electrophilic reactivity of α,β-unsaturated amides towards weak nucleophiles such as arenes and cyclohexane, initiated either with triflic acid (CF3SO3H) or with excess AlCl3, has been studied. The amides generally condense readily with aromatics in the presence of AlCl3 to give 3-arylpropionamides and related compounds in excellent yields, while some amides also undergo selective ionic hydrogenation
    已经研究了用三氟甲磺酸 (CF3SO3H) 或过量 AlCl3 引发的 α,β-不饱和酰胺对弱亲核试剂如芳烃和环己烷的亲电反应性。在 AlCl3 存在下,酰胺通常很容易与芳烃缩合,以极好的收率得到 3-芳基丙酰胺和相关化合物,而一些酰胺也可以与环己烷进行选择性离子氢化,得到饱和酰胺。这些反应的拟议机制涉及双阳离子中间体(超亲电试剂)。报告了对双阳离子物质的直接观察(通过低温 NMR)。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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