双(4-氯苯基)(吡啶-2-基)甲醇 | 101875-96-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 双(4-氯苯基)(吡啶-2-基)甲醇
• 英文名称: bis(4-chlorophenyl)(pyridin-2-yl)methanol
• 英文别名: bis(4-chlorophenyl)-pyridin-2-ylmethanol
• CAS: 101875-96-1
• 化学式: C₁₈H₁₃Cl₂NO
• 分子量: 330.213
• InChiKey: ZFWSKDPSRKGSHL-UHFFFAOYSA-N

物化性质

• 熔点：
  88-89 °C
• 沸点：
  476.1±40.0 °C(Predicted)
• 密度：
  1.334±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  双(4-氯苯基)(吡啶-2-基)甲醇 在 甲酸 作用下， 反应 7.0h， 以97%的产率得到7-chloro-10-(4-chlorophenyl)pyrido[1,2-a]indole
  参考文献：
  名称：

  An efficient synthesis of pyrido[1,2-a]indoles through aza-Nazarov type cyclization

  摘要：

  通过使用甲酸介导的过渡金属无机酸催化合成，已经开发出一种通过可获得的二芳基(2-吡啶基)甲醇进行氮杂Nazarov型环化反应，合成具有生物学和药用重要性的吡啶[1,2-a]吲哚、吲哚[1,2-a]喹啉和嘧啶[1,2-a]吲哚衍生物的方法。

  DOI：

  10.1039/c4cc08783f
• 作为产物：
  描述：

  4-溴氯苯 、 2-吡啶甲酸乙酯 在 碘 、 magnesium 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 双(4-氯苯基)(吡啶-2-基)甲醇
  参考文献：
  名称：

  An efficient synthesis of pyrido[1,2-a]indoles through aza-Nazarov type cyclization

  摘要：

  通过使用甲酸介导的过渡金属无机酸催化合成，已经开发出一种通过可获得的二芳基(2-吡啶基)甲醇进行氮杂Nazarov型环化反应，合成具有生物学和药用重要性的吡啶[1,2-a]吲哚、吲哚[1,2-a]喹啉和嘧啶[1,2-a]吲哚衍生物的方法。

  DOI：

  10.1039/c4cc08783f

文献信息

• Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups
  作者：C. David Jones、Mark A. Winter、Kenneth S. Hirsch、Nancy Stamm、Harold M. Taylor、Howard E. Holden、James D. Davenport、Eriks V. Krumkalns、Robert G. Suhr

  DOI：10.1021/jm00163a065

  日期：1990.1

  The preparation and in vitro aromatase inhibitory activity of a wide variety of heterocyclic (4,4'-dichlorodiphenyl)methanes and -methanols are described. The choice of the two diaryl-bearing moieties as a vehicle for the evaluation of the heterocycles was made by the comparison of series of imidazole and pyridine-derived compounds with similar pyrimidine compounds reported previously. A structural

  描述了多种杂环（4,4'-二氯二苯基）甲烷和-甲醇的制备和体外芳香酶抑制活性。通过将一系列咪唑和吡啶衍生的化合物与先前报道的类似嘧啶化合物进行比较，从而选择了两个带有二芳基的部分作为评估杂环的载体。还介绍了活性最高的化合物的结构模型。发现包含两个杂环部分的一系列相关化合物的活性与模型一致。评估的许多化合物（包括吡啶，咪唑，嘧啶，吡唑，三唑，噻唑和异噻唑类的代表）在低纳摩尔浓度下均具有EC50抑制芳香酶的能力。
• 유기 화합물 및 이를 포함하는 유기 전계 발광 소자
  申请人：Solus Advanced Materials co., Ltd. 솔루스첨단소재 주식회사(120190660630) Corp. No ▼ 214911-0058927BRN ▼668-81-01406

  公开号：KR20190033218A

  公开（公告）日：2019-03-29

  본 발명은 신규 화합물 및 이를 포함하는 유기 전계 발광 소자에 관한 것으로서, 본 발명에 따른 화합물은 유기 전계 발광 소자의 유기물층, 바람직하게는 발광층에 사용됨에 따라 유기 전계 발광 소자의 발광 효율, 구동 전압, 수명 등을 향상시킬 수 있다.

  这项发明涉及一种新化合物及其包含的有机电致发光器件，根据本发明的化合物可用于有机电致发光器件的有机层，特别是用于发光层，可以提高有机电致发光器件的发光效率、驱动电压和寿命等。
• A molded antimicrobial article and a process for its production
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0952248A2

  公开（公告）日：1999-10-27

  A molded antimicrobial article comprises an infiltrated antimicrobial agent which forms independent phases of 0.01 µm or more in shorter diameter in the molded article. It is preferable that the antimicrobial agent is a pyridine based antimicrobial agent with a molecular weight of 200 to 700 and an inorganic property/organic property value of 0.3 to 1, and that 50% or more of the antimicrobial agent is infiltrated in a depth range of 0.5, preferably, 1 µm or more from the surface of the molded article, or that 30% or more of the antimicrobial agent is infiltrated in a depth range of 2 µm or more from the surface of the molded article. It is also preferable that the molded article is fibers, that the surface area used per 1 g of fibers is 0.1 m2 or more, and that the synthetic fibers are a colored antimicrobial fibrous product. The molded antimicrobial article of the present invention can be obtained, for example, by immersing a fibrous product in a dyeing liquid containing a pyridine based antimicrobial agent with a molecular weight of 200 to 700, an inorganic property/organic property value of 0.3 to 1.4 and an average particle size of 2 µm or less, and treating simultaneously with dyeing under pressurization, or by applying a liquid containing a pyridine based antimicrobial agent with a molecular weight of 200 to 700, an inorganic property/organic property value of 0.3 to 1.4 and an average particle size of 2 µm or less to a fibrous product by padding or spraying, and heat-treating it at 160 to 200°C in dry or wet state.

  一种模塑抗菌制品包括一种浸润抗菌剂，该抗菌剂在模塑制品中形成短直径为 0.01 微米或以上的独立相。抗菌剂最好是基于吡啶的抗菌剂，分子量在 200 到 700 之间，无机性质/有机性质值在 0.3 到 1 之间，50%或更多的抗菌剂浸润在距离模塑制品表面 0.5 微米（最好是 1 微米）或更大的深度范围内，或者 30%或更多的抗菌剂浸润在距离模塑制品表面 2 微米或更大的深度范围内。此外，成型品最好是纤维，每 1 克纤维使用的表面积为 0.1 平方米或以上，合成纤维最好是有色抗菌纤维制品。 本发明的模塑抗菌制品可通过将纤维制品浸入含有吡啶类抗菌剂的染色液中获得，吡啶类抗菌剂的分子量为 200 至 700，无机性质/有机性质值为 0.3 至 1.4 和平均粒径为 2 微米或更小的吡啶基抗菌剂的染色液中，并在加压下与染色同时进行处理，或通过轧制或喷涂将含有分子量为 200 至 700、无机物特性/有机物特性值为 0.3 至 1.4 和平均粒径为 2 微米或更小的吡啶基抗菌剂的液体涂抹到纤维制品上，并在 160 至 200°C 的干燥或湿润状态下进行热处理。
• ANTIBACTERIAL COMPOSITION, ANTIBACTERIAL MOLDING, SOLUTION CONTAINING ANTIBACTERIAL COMPOSITION, DETERGENT, SURFACE OF TATAMI MAT AND TATAMI MAT
  申请人：Idemitsu Technofine Co. Ltd

  公开号：EP1779727A1

  公开（公告）日：2007-05-02

  An antibacterial composition containing an organic antibacterial agent and an inorganic antibacterial agent is provided. Zirconium phosphate having supported thereon silver or copper or a salt thereof may be used as the inorganic antibacterial agent, and 2-mercaptopyridine-N-oxide sodium, carbendazim (methyl 1H-2-benzimidazole carbamate), or thiabendazole (2-(4-thiazolyl)-1H-benzimidazole) may be used as the organic antibacterial agent. Those components contain no halogen, so the antibacterial composition can be made halogen-free. The antibacterial composition may be applied to form an antibacterial molding, for example, by molding it together with a resin material or applying it together with a coating agent on a resin molding.

  提供了一种含有有机抗菌剂和无机抗菌剂的抗菌组合物。无机抗菌剂可使用磷化锆，磷化锆上支持银或铜或其盐，有机抗菌剂可使用 2-巯基吡啶-N-氧化钠、多菌灵（1H-2-苯并咪唑氨基甲酸甲酯）或噻菌灵（2-(4-噻唑基)-1H-苯并咪唑）。这些成分不含卤素，因此可以制成无卤抗菌组合物。抗菌组合物可用于形成抗菌模塑件，例如与树脂材料一起模塑或与涂层剂一起涂抹在树脂模塑件上。
• AGENT FOR IMPARTING ANTI-BACTERIAL/ANTI-FUNGAL PROPERTIES, FIBER PROCESSING AGENT, AND PRODUCTION METHOD FOR ANTI-BACTERIAL/ANTI-FUNGAL FIBER
  申请人：Osaka Kasei Co., Ltd.

  公开号：EP2769620A1

  公开（公告）日：2014-08-27

  An object of the present invention is to make it possible that a pyridine antibacterial/antifungal agent is dispersed stably in a liquid for appropriate impartation of the pyridine antibacterial/antifungal agent to fibers, and that when fibers are processed with the agent which is mixed with various other treating agents such as dyes and softeners, there is no negative influences on the process of the fibers for imparting antibacterial/antifungal properties. An antibacterial/antifungal properties-imparting agent contains a pyridine antibacterial/antifungal agent; a modified polysaccharide having reduced hydroxyl groups; and a wetting agent; but does not contain a surfactant. After applying the antibacterial/antifungal properties-imparting agent to fibers, the fibers undergo a heating process.

  本发明的目的是使吡啶抗菌/抗真菌剂能稳定地分散在液体中，以适当地将吡啶抗菌/抗真菌剂赋予纤维，并且当纤维与混合了各种其他处理剂（如染料和柔软剂）的药剂一起加工时，不会对纤维赋予抗菌/抗真菌特性的过程产生负面影响。一种抗菌/抗真菌剂含有吡啶抗菌/抗真菌剂、具有还原羟基的改性多糖和润湿剂，但不含表面活性剂。在纤维上涂抹抗菌/抗真菌性能诱导剂后，对纤维进行加热处理。