1-Pyrenylsulfate | 154717-06-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: 1-Pyrenylsulfate
• 英文别名: pyren-1-yl hydrogen sulfate
• CAS: 154717-06-3
• 化学式: C₁₆H₁₀O₄S
• 分子量: 298.3
• InChiKey: PPWRGGIIPLXGJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Novel green and orange fluorescent labels and their uses
  申请人：——

  公开号：US20040106806A1

  公开（公告）日：2004-06-03

  The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative flourescent detection of low levels of biomolecules. In a preferred embodiment, the flourescent labels of this invention are novel derivatives of the hydroxy-pyrene trisulphonic and disulphonic acids which may be used in any assay in which radioisotopes, colored dyes or other fluorescent molecules are currently used. Thus, for example, any assay using labeled antibodies, proteins, oligonucleotides or lipids, including fluorescent cell sorting, fluorescence microscopy (including dark-field microscopy), fluorescence polarization assays, ligand, receptor binding assays, receptor activation assays and diagnostic assays can benefit from use of the compounds disclosed herein.

  本发明提供了新型荧光化合物和共价连接化学品，这些化合物可作为标记物，用于超灵敏和定量检测低水平生物分子的荧光检测。在一种首选实施方式中，本发明的荧光标记物是羟基吡啶三磺酸和二磺酸的新型衍生物，可用于任何目前使用放射性同位素、有色染料或其他荧光分子的检测中。因此，例如，任何使用标记抗体、蛋白质、寡核苷酸或脂质的检测方法，包括荧光细胞分选、荧光显微镜（包括暗场显微镜）、荧光偏振测定、配体、受体结合测定、受体激活测定和诊断测定，都可以从本文所披露的化合物的使用中获益。
• Light emitting markers for use with substrates
  申请人：——

  公开号：US20030015284A1

  公开（公告）日：2003-01-23

  A method of determining whether a substrate has been subjected to an energy source. In one embodiment, the method includes the steps of providing a polymeric surface, providing a light emitting material having a specified emission spectrum that changes upon exposure to an energy source on the surface or embedded in said substrate and applying said energy source to said surface with said light emitting material. This method can be particularly useful for detecting the bond quality in medical devices.

  一种确定基底是否经受过能量源的方法。在一个实施方案中，该方法包括以下步骤：提供聚合物表面；提供具有特定发射光谱的发光材料，该材料在表面或嵌入所述基底中暴露于能量源后会发生变化；将所述能量源与所述发光材料一起应用于所述表面。这种方法尤其适用于检测医疗设备的粘接质量。
• Fluorescent dyed lubricant for medical devices
  申请人：——

  公开号：US20030018353A1

  公开（公告）日：2003-01-23

  A composition and method for detecting the presence, location and uniformity of a lubricious coating on a medical device. The method includes the steps of preparing a mixture of a biocompatible hydrophilic fluorescent dye and a hydrophobic lubricant, applying the mixture to the surface of a medical device to form a coating capable of exhibiting fluorescence, and subjecting the surface of the medical device to a source of energy capable of inducing a fluorescent emission. The coating composition may further comprise a surfactant. This method finds particular utility for catheters, especially stent delivery catheters.

  一种用于检测医疗器械上润滑涂层的存在、位置和均匀性的组合物和方法。该方法包括以下步骤：制备生物相容性亲水性荧光染料和疏水性润滑剂的混合物，将该混合物涂抹到医疗设备表面以形成能够发出荧光的涂层，以及将医疗设备表面置于能够诱发荧光发射的能量源下。涂层组合物可进一步包含表面活性剂。这种方法特别适用于导管，尤其是支架输送导管。
• Pyrenyloxysulfonic acid fluorescent agents
  申请人：Haugland Richard

  公开号：US20050123935A1

  公开（公告）日：2005-06-09

  The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.

  本发明提供了一类基于芘磺酸核的新型活性荧光剂。通过使活性基团与共轭物中其他物质上具有互补反应性的基团反应，这些制剂很容易与其他物质结合成共轭物。此外，还提供了使用本发明化合物检测和/或量化样品中分析物的方法。在一个示例性实施方案中，本发明提供了包含本发明化合物的多色检测方法。
• NOVEL GREEN AND ORANGE FLUORESCENT LABELS AND THEIR USES
  申请人：Chromagen, Inc.

  公开号：EP1546673A2

  公开（公告）日：2005-06-29