DG (44:0)

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: DG (44:0)
• 英文别名: 1,2-di-O-docosanoyl-Sn-glycerol；1,2-Didocosanoyl-sn-glycerol；[(2S)-2-docosanoyloxy-3-hydroxypropyl] docosanoate
• 化学式: C₄₇H₉₂O₅
• 分子量: 737.244
• InChiKey: GNWCZBXSKIIURR-GWHBCOKCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  20.5
• 重原子数：
  52
• 可旋转键数：
  46
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  、 DG (44:0) 以4%的产率得到3-O-[methyl (5-acetamido-4,7,8,9-tetra-O-levulinoyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosyl)onate]-1,2-di-O-docosanoyl-Sn-glycerol
  参考文献：
  名称：

  Compounds comprising sulfated nonulonic acid having antiviral activity

  摘要：

  为了提供具有低抗凝作用和低细胞毒性的抗逆转录病毒活性化合物，提供了包含糖苷或其盐的化合物，其中脂质连接到唾液酸的第2位，其4、7、8和9位的所有羟基完全磺酸化，或者KDN（2-酮-3-脱氧-D-甘油酸）的4、5、7、8和9位的所有羟基完全磺酸化。

  公开号：

  US06337390B1
• 作为产物：
  描述：

  3-O-benzyl-1,2-di-O-docosanoyl-Sn-glycerol 以88%的产率得到DG (44:0)
  参考文献：
  名称：

  Compounds comprising sulfated nonulonic acid having antiviral activity

  摘要：

  为了提供具有低抗凝作用和低细胞毒性的抗逆转录病毒活性化合物，提供了包含糖苷或其盐的化合物，其中脂质连接到唾液酸的第2位，其4、7、8和9位的所有羟基完全磺酸化，或者KDN（2-酮-3-脱氧-D-甘油酸）的4、5、7、8和9位的所有羟基完全磺酸化。

  公开号：

  US06337390B1

文献信息

• Novel compounds having antiviral activity
  申请人：Nissin Food Products Co., Ltd.

  公开号：US20020077472A1

  公开（公告）日：2002-06-20

  In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position 2 of sialic acid having all hydroxyl groups at positions 4, 7, 8 and 9 completely sulfated, or KDN (2-keto-3-deoxy-D-glycero-2-nononic acid) having all hydroxyl groups at positions 4, 5, 7, 8 and 9 completely sulfated are provided.

  为了提供具有低抗凝作用和低细胞毒性的抗逆转录病毒活性化合物，提供了由苷或其盐组成的化合物，其中脂质与位置 4、7、8 和 9 的所有羟基完全硫酸化的硅烷酸的位置 2 相连，或位置 4、5、7、8 和 9 的所有羟基完全硫酸化的 KDN（2-酮基-3-脱氧-D-甘油-2-壬酸）。
• NOVEL COMPOUNDS HAVING ANTIVIRAL ACTIVITY
  申请人：NISSIN FOOD PRODUCTS CO., LTD.

  公开号：EP0957107B1

  公开（公告）日：2004-07-21
• LIPOSOME COMPOSITIONS FOR IN VIVO ADMINISTRATION OF BORONIC ACID COMPOUNDS
  申请人：Huang Anthony

  公开号：US20090092661A1

  公开（公告）日：2009-04-09

  Liposome formulations for administration of a boronic acid compound are described. The liposomes are comprised of a phospholipid having two acyl chains with between 20-22 carbon atoms in each chain and a boronic acid compound entrapped in the liposomes. In a preferred embodiment, the boronic acid compound is in the form of a complex with meglumine.
• MICROBUBBLES AND METHODS FOR OXYGEN DELIVERY
  申请人：Kheir John

  公开号：US20090191244A1

  公开（公告）日：2009-07-30

  Compositions containing a carrier and microbubles encapsulating one or more gases, preferably oxygen, and methods for making and using the compositions are described herein. The microbubbles contain a lipid envelope formed of at least one base lipid and at least one emulsifying agent. The compositions may be administered to a patient to quickly deliver large amounts of oxygen to the patient's blood supply or directly to a tissue in need of oxygen. The compositions may be administered via injection or as a continuous infusion. The compositions contain a concentrated microbubble suspension, where the suspension contains at least 40 mL oxygen/dL suspension. The microbubbles are preferably less than 20 microns in diameter, more preferably less than 15 microns in diameter. The microbubbles described herein may be administered to a patient in an effective amount to increase in oxygen concentration in the patient's blood, and/or one or more tissues or organs. The microbubbles may be administered alone or in combination with other treatments as an adjuctive therapy.
• US6337390B1
  申请人：——

  公开号：US6337390B1

  公开（公告）日：2002-01-08