2-(1H-benzimidazol-2-ylsulfanyl)-N'-{(E)-[4-(diethylamino)phenyl]methylidene}acetohydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(1H-benzimidazol-2-ylsulfanyl)-N'-{(E)-[4-(diethylamino)phenyl]methylidene}acetohydrazide
• 英文别名: 2-(1H-benzimidazol-2-ylsulfanyl)-N-[(E)-[4-(diethylamino)phenyl]methylideneamino]acetamide
• 化学式: C₂₀H₂₃N₅OS
• 分子量: 381.5
• InChiKey: JHLFAKRQTJUHGG-FYJGNVAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  98.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• ADENYLYL CYCLASES AS NOVEL TARGETS FOR THE TREATMENT OF INFECTION BY EUKARYOTIC PATHOGENS
  申请人：Levin Lonny

  公开号：US20100063099A1

  公开（公告）日：2010-03-11

  The present invention relates to a method of preventing or treating a disease caused by infection by a eukaryotic pathogen, wherein the method comprises administering an effective amount of a modulator of a eukaryotic pathogen's adenylyl cyclase. The invention also provides pharmaceutical compositions useful for preventing or treating a disease, with the compositions containing a therapeutically effective amount of a modulator of a eukaryotic pathogen's adenylyl cyclase. The invention also provides screening methods for identifying selective modulators of a eukaryotic pathogen's adenylyl cyclase that do not substantially modulate an adenylyl cyclase of the subject. The invention also provides methods for culturing eukaryotic pathogens and methods for inducing the pathogenic state in vitro.
• ADENYLYL CYCLASES AS NOVEL TARGETS FOR ANTIBACTRIAL INTERVENTIONS
  申请人：Levin Lonny

  公开号：US20100168203A1

  公开（公告）日：2010-07-01

  The present invention relates to a method of preventing or treating a disease caused by bacterial infection by administering an effective amount of a modulator of bacterial adenylyl cyclase. The invention also provides pharmaceutical compositions useful for preventing or treating a disease, with the compositions containing a therapeutically effective amount of a modulator of bacterial adenylyl cyclase. The invention also provides screening methods for identifying selective modulators of bacterial adenylyl cyclase that do not substantially modulate adenylyl cyclase of the subject. The invention also provides methods for culturing bacterial pathogens and methods for inducing the pathogenic state in vitro.
• METHOD TO TREAT PSORIASIS AND OTHER HYPERPROLIFERATIVE SKIN DISORDERS
  申请人：Buck Jochen

  公开号：US20110305640A1

  公开（公告）日：2011-12-15

  Soluble adenylyl cyclase (sAC) is implicated in proliferation of keratinocytes. Inhibitors of sAC are useful for the treatment and/or prevention of psoriasis and other hyperproliferative skin disorders. Assays to identify such compounds are also described.
• US9017681B2
  申请人：——

  公开号：US9017681B2

  公开（公告）日：2015-04-28
• US9095578B2
  申请人：——

  公开号：US9095578B2

  公开（公告）日：2015-08-04