1-fluoro-4,5-dimethoxy-2-vinylbenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-fluoro-4,5-dimethoxy-2-vinylbenzene
• 英文别名: 1-Ethenyl-2-fluoro-4,5-dimethoxybenzene；1-ethenyl-2-fluoro-4,5-dimethoxybenzene
• 化学式: C₁₀H₁₁FO₂
• 分子量: 182.195
• InChiKey: VUGVCEKTPBGQNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二溴丙二酸二乙酯 、 1-fluoro-4,5-dimethoxy-2-vinylbenzene 在 fac-tris(2-phenylpyridinato-N,C2')iridium(III) 、 dipotassium hydrogenphosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以76%的产率得到ethyl 2-ethoxy-5-(2-fluoro-4,5-dimethoxyphenyl)furan-3-carboxylate
  参考文献：
  名称：

  Photoredox Divergent 1,2-Difunctionalization of Alkenes with gem-Dibromides

  摘要：

  The redox neutral photocatalytic divergent radical 1,2-difunctionalization of a wide array of structurally varied alkenes with gem-dibromides is presented. On the basis of the electronic effect of alkenes, predictable 1,2-carboxygenation and 1,2-carbohalogenation of alkenes are readily available regardless of steric effect. This protocol affords a practical approach to the biologically important furan skeleton. It is distinguished by good regioselectivity, good functional group compatibility, and late-stage modification and thus signifies an important step forward to divergent radical difunctionalization of alkenes.

  DOI：

  10.1021/acs.orglett.7b03371

文献信息

• [EN] CHEMICAL COMPOUNDS 251<br/>[FR] COMPOSÉS CHIMIQUES 251
  申请人：ASTRAZENECA AB

  公开号：WO2010001169A2

  公开（公告）日：2010-01-07

  The invention relates to chemical compounds of formula (I), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of PIM-1 and/or PIM-2, and/or PIM-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of PIM kinase related conditions and diseases, preferably cancer.
• Photoredox Divergent 1,2-Difunctionalization of Alkenes with <i>gem</i>-Dibromides
  作者：Jian Cheng、Yixiang Cheng、Jin Xie、Chengjian Zhu

  DOI：10.1021/acs.orglett.7b03371

  日期：2017.12.1

  The redox neutral photocatalytic divergent radical 1,2-difunctionalization of a wide array of structurally varied alkenes with gem-dibromides is presented. On the basis of the electronic effect of alkenes, predictable 1,2-carboxygenation and 1,2-carbohalogenation of alkenes are readily available regardless of steric effect. This protocol affords a practical approach to the biologically important furan skeleton. It is distinguished by good regioselectivity, good functional group compatibility, and late-stage modification and thus signifies an important step forward to divergent radical difunctionalization of alkenes.