N-ethyl-N,N-dimethyl-2-(vinyloxy)ethylammonium chloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-ethyl-N,N-dimethyl-2-(vinyloxy)ethylammonium chloride
• 英文别名: 2-Ethenoxyethyl-ethyl-dimethylazanium;chloride；2-ethenoxyethyl-ethyl-dimethylazanium;chloride
• 化学式: C₈H₁₈NO*Cl
• 分子量: 179.69
• InChiKey: MTCBZNORQBPSEQ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.75
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二甲基十二/十四烷基叔胺 、 2-氯乙基乙烯基醚 以 甲醇 为溶剂， 125.0 ℃ 、310.26 kPa 条件下， 反应 72.0h， 以99%的产率得到N-ethyl-N,N-dimethyl-2-(vinyloxy)ethylammonium chloride
  参考文献：
  名称：

  Liquid-Core Capsules via Interfacial Polymerization:  A Free-Radical Analogy of the Nylon Rope Trick

  摘要：

  Liquid-core capsules have wide-ranging applications in the high-efficiency encapsulation and controlled release of drugs, dyes, enzymes, and other substrates. Their great utility has driven the rapid development of various preparation techniques. However, there remains no convenient technique for the preparation of submicrometer liquid-core capsules with shell thicknesses less than 100 nm. Here, we demonstrate a new interfacial free-radical polymerization approach for the straightforward preparation of liquid-core polymer capsules. Conceptually, this interfacial free-radical polymerization is analogous to the classical "nylon rope trick" wherein hydrophobic and hydrophilic monomers alternately copolymerize to constrain the polymerization at interfaces, but its free-radical mechanism allows precise control of initiation, which makes it possible to finely disperse the immiscible phases prior to polymerization.

  DOI：

  10.1021/ja044532h

文献信息

• Liquid core capsules and methods of synthesis thereof through interfacial polymerization
  申请人：Wu Dan

  公开号：US20060127490A1

  公开（公告）日：2006-06-15

  A process for the encapsulation of liquid particles within nanometer thick polymer shells utilizes an interfacial free radical alternating copolymerization process. Encapsulating a liquid material includes providing a mixture comprising the liquid material to be encapsulated, a hydrophobic monomer in a non-polar solution and a hydrophilic monomer in a polar solution. The liquid material is compatible in either the polar solution or the non-polar solution. The polar solution and the non-polar solution are not miscible in each other. The mixture is homogenized to form an emulsion, and then polymerized by an initiator which initiates an interfacial free radical alternating copolymerization process. The copolymerization process is optimally constrained to proceed only at the hydrophobic and hydrophilic interface thus forming a polymer around the liquid material.

  一种用于在纳米厚度聚合物壳内封装液体颗粒的过程利用界面自由基交替共聚合过程。封装液体材料包括提供包括待封装的液体材料、疏水单体在非极性溶液中和亲水单体在极性溶液中的混合物。液体材料与极性溶液或非极性溶液中的任一种兼容。极性溶液和非极性溶液在彼此中不互溶。混合物经均质化形成乳液，然后由引发剂聚合，引发界面自由基交替共聚合过程。共聚合过程在最佳条件下仅受限于在疏水和亲水界面进行，从而形成液体材料周围的聚合物。
• Liquid-Core Capsules via Interfacial Polymerization:  A Free-Radical Analogy of the Nylon Rope Trick
  作者：Charles Scott、Dan Wu、Chia-Chi Ho、Carlos C. Co

  DOI：10.1021/ja044532h

  日期：2005.3.1

  Liquid-core capsules have wide-ranging applications in the high-efficiency encapsulation and controlled release of drugs, dyes, enzymes, and other substrates. Their great utility has driven the rapid development of various preparation techniques. However, there remains no convenient technique for the preparation of submicrometer liquid-core capsules with shell thicknesses less than 100 nm. Here, we demonstrate a new interfacial free-radical polymerization approach for the straightforward preparation of liquid-core polymer capsules. Conceptually, this interfacial free-radical polymerization is analogous to the classical "nylon rope trick" wherein hydrophobic and hydrophilic monomers alternately copolymerize to constrain the polymerization at interfaces, but its free-radical mechanism allows precise control of initiation, which makes it possible to finely disperse the immiscible phases prior to polymerization.