(R)-1-phenylbutyl 2,4-dinitrobenzenesulfenate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-1-phenylbutyl 2,4-dinitrobenzenesulfenate
• 英文别名: 2,4-dinitro-1-[(1R)-1-phenylbutoxy]sulfanylbenzene
• 化学式: C₁₆H₁₆N₂O₅S
• 分子量: 348.379
• InChiKey: JHYRASNTAOZBJA-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  126
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (R)-(+)-1-苯基-1-丁醇 、 2,4-二硝基苯硫氯 在 吡啶 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 0.5h， 以49.6%的产率得到(R)-1-phenylbutyl 2,4-dinitrobenzenesulfenate
  参考文献：
  名称：

  A correlation between the absolute configurations of acyclic aliphatic and benzylic secondary alcohols and the optical rotations of their 2,4-dinitrobenzenesulfenyl derivatives

  摘要：

  The 2,4-dinitrobenzenesulfenate esters 2a-v of 11 acyclic aliphatic and 11 benzylic chiral secondary alcohols of known configuration were synthesized, and their sodium D line optical rotations and CD spectra were determined. The sign of the sodium D line rotations of the derivatives was consistently correlated with the absolute configuration of the carbinol carbon in the original alcohols. The CD spectra exhibited optically active transitions in the 320-400-nm region that corresponded in sign to the sodium D line optical rotations and were strong enough to dominate the sign of rotation at the sodium D line. Thus the optical rotations and CD spectra of these sulfenate ester derivatives are diagnostic for the absolute configurations of chiral secondary acyclic aliphatic and benzylic alcohols.

  DOI：

  10.1021/jo00057a044

文献信息

• A correlation between the absolute configurations of acyclic aliphatic and benzylic secondary alcohols and the optical rotations of their 2,4-dinitrobenzenesulfenyl derivatives
  作者：Leslie E. Craine、Laura K. Bicknell、Renee C. Mailloux、Jonathan P. Mark、Scott A. Mitchell、Santiago R. Vicente、Jerry P. Jasinski、Richard C. Woudenberg

  DOI：10.1021/jo00057a044

  日期：1993.2

  The 2,4-dinitrobenzenesulfenate esters 2a-v of 11 acyclic aliphatic and 11 benzylic chiral secondary alcohols of known configuration were synthesized, and their sodium D line optical rotations and CD spectra were determined. The sign of the sodium D line rotations of the derivatives was consistently correlated with the absolute configuration of the carbinol carbon in the original alcohols. The CD spectra exhibited optically active transitions in the 320-400-nm region that corresponded in sign to the sodium D line optical rotations and were strong enough to dominate the sign of rotation at the sodium D line. Thus the optical rotations and CD spectra of these sulfenate ester derivatives are diagnostic for the absolute configurations of chiral secondary acyclic aliphatic and benzylic alcohols.