2,4-di-tert-butyl-6-(4'-methylbenzyl)phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-di-tert-butyl-6-(4'-methylbenzyl)phenol
• 英文别名: 2,4-Ditert-butyl-6-[(4-methylphenyl)methyl]phenol
• 化学式: C₂₂H₃₀O
• 分子量: 310.48
• InChiKey: MAOSIAZBKALVDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,4-二叔丁基苯酚 、 4-甲基氯苄 在 zinc(II) chloride 作用下， 以 氯仿 为溶剂， 反应 72.0h， 以8%的产率得到2,4-di-tert-butyl-6-(4'-methylbenzyl)phenol
  参考文献：
  名称：

  Substituent effects on chemosterilant activity of 2,4-di-tert-butyl-6-(4'-substituted benzyl)phenols in the house fly (Musca domestica L.)

  摘要：

  A series of 2,4-di-tert-butyl-6-(4'-X-benzyl)phenols was prepared, analogous to the compound Jurd 2644 (X = OMe) in an attempt to establish a Hammett relationship between the 4'-substituent and the chemosterilant activity of the compounds after oral administration to adult Musca domestica. Fourteen compounds of this type were prepared, 12 of them new. Jurd 2419 (X = H) was found to be as active in our bioassay as Jurd 2644, as were four new compounds [X = N(CH3)(2), CH3, SCH3, Cl]. All prevented successful reproduction at 30 mg/kg of diet. There was no correlation between Hammett a and activity. Active compounds all had small substituents and molecular weights below 350. The activity seemed to be determined by the bulk of X rather than by its electronic properties.

  DOI：

  10.1021/jf00059a037

文献信息

• Convenient Synthesis of 2,2′- and 4,4′-Methylenebisphenols with Bulky Alkyl Substituents and Evaluation of Their Antioxidant Activity
  作者：Evgeny V. Buravlev、Irina Yu. Chukicheva、Mikhail F. Borisenkov、Aleksandr V. Kutchin

  DOI：10.1080/00397911.2011.589564

  日期：2012.12.15

  The work is devoted to a convenient procedure of the synthesis of 2,2'- and 4,4'-methylenebisphenols with alkyl substituents in heterogeneous catalysis. This compounds were obtained with yields up to 87% by reflux of 2,4- or 2,6-dialkylphenols with HCHO in n-octane in the presence of KSF clay. We found that the antioxidant activity on DPPH test for two novel methylenebisphenols having isobornyl fragments was comparable with control drugs.
• Substituent effects on chemosterilant activity of 2,4-di-tert-butyl-6-(4'-substituted benzyl)phenols in the house fly (Musca domestica L.)
  作者：Jan Kochansky、Charles F. Cohen、William R. Lusby

  DOI：10.1021/jf00059a037

  日期：1995.11

  A series of 2,4-di-tert-butyl-6-(4'-X-benzyl)phenols was prepared, analogous to the compound Jurd 2644 (X = OMe) in an attempt to establish a Hammett relationship between the 4'-substituent and the chemosterilant activity of the compounds after oral administration to adult Musca domestica. Fourteen compounds of this type were prepared, 12 of them new. Jurd 2419 (X = H) was found to be as active in our bioassay as Jurd 2644, as were four new compounds [X = N(CH3)(2), CH3, SCH3, Cl]. All prevented successful reproduction at 30 mg/kg of diet. There was no correlation between Hammett a and activity. Active compounds all had small substituents and molecular weights below 350. The activity seemed to be determined by the bulk of X rather than by its electronic properties.