aminomethyl-4,5',8-trimethylpsoralen | 225379-29-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: aminomethyl-4,5',8-trimethylpsoralen
• 英文别名: 3-aminomethyl-4,5',8-trimethylpsoralen；6-(Aminomethyl)-2,5,9-trimethylfuro[3,2-g]chromen-7-one
• CAS: 225379-29-3
• 化学式: C₁₅H₁₅NO₃
• 分子量: 257.289
• InChiKey: BWXOXDZDKVNDSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Psoralens for pathogen inactivation
  申请人：Cerus Corporation

  公开号：US20030082510A1

  公开（公告）日：2003-05-01

  Psoralen compound compositions are synthesized which have primaryamino substitutions on the 3-, 4-, 5-, and 8-positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these psoralens result in the inactivation of pathogens which contain nucleic acid. The compounds show similar activity in test systems to 4′ and 5′ derivatives of psoralen useful for inactivation of pathogens in blood products. In addition to the psoralen compositions, the invention contemplates such inactivating methods using the new psoralens.

  合成了一种含有3-、4-、5-和8-位置的主要氨基取代基的芳香光毒素化合物组合物，但仍允许它们与病原体的核酸结合。光活化这些芳香光毒素的反应条件导致含有核酸的病原体失活。这些化合物在测试系统中显示出与用于血液制品中病原体失活的4'和5'衍生物的类似活性。除了芳香光毒素组合物外，本发明还考虑使用新的芳香光毒素进行失活方法。
• Pulse photodynamic treatment of photodamaged skin
  申请人：GALDERMA RESEARCH & DEVELOPMENT

  公开号：US10716855B2

  公开（公告）日：2020-07-21

  A pulse photodynamic therapy (or pulse PDT) treatment of photodamaged skin is described.

  本文介绍了脉冲光动力疗法（或脉冲光动力疗法）治疗光损伤皮肤的方法。
• Methods for inducing the differentiation of monocytes into functional dendritic cells
  申请人：——

  公开号：US20010053355A1

  公开（公告）日：2001-12-20

  A method for inducing differentiation of monocytes contained in an extracorporeal quantity of a subject's blood into functional dendritic antigen presenting cells is provided. The monocytes are first treated by exposure to physical perturbation, irradiation in the presence of a photoactivatable agent capable of forming photoadducts with cellular DNA components, and/or treatment with a DNA binding agent. The treated monocytes are then incubated for a period of time sufficient to maximize the number of functional dendritic cells in the treated cell population. Functional dendritic cells generated from induced monocytes are incubated together with disease effector agents to enhance the presentation of at least one disease-causing antigen expressed by the disease effector agents.

  本发明提供了一种方法，可诱导体外量受试者血液中的单核细胞分化为功能性树突状抗原呈递细胞。首先对单核细胞进行物理扰动处理，在有能与细胞 DNA 成分形成光加合物的光活化剂存在的情况下进行照射，和/或用 DNA 结合剂处理。然后将处理过的单核细胞培养一段时间，使处理过的细胞群中功能性树突状细胞的数量达到最大。将诱导单核细胞产生的功能树突状细胞与疾病效应剂一起培养，以增强疾病效应剂表达的至少一种致病抗原的表达。
• EP1032265A4
  申请人：——

  公开号：EP1032265A4

  公开（公告）日：2001-05-30
• NEW PSORALENS FOR PATHOGEN INACTIVATION
  申请人：Cerus Corporation

  公开号：EP1032265B1

  公开（公告）日：2003-10-29