Oxacyclohenicos-11-yn-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: Oxacyclohenicos-11-yn-2-one
• 英文别名: 1-Oxacyclohenicos-11-yn-2-one
• 化学式: C₂₀H₃₄O₂
• 分子量: 306.489
• InChiKey: OSISDJGABZHDEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Dodec-10-ynoic acid dodec-10-ynyl ester 在 作用下， 以 氯苯 为溶剂， 以52%的产率得到Oxacyclohenicos-11-yn-2-one
  参考文献：
  名称：

  Ring-Closing Metathesis of Functionalized Acetylene Derivatives: A New Entry into Cycloalkynes

  摘要：

  A tungsten alkylidyne catalyst is the key to achieving ring-closing metatheses of diynes to form functionalized macrocycles [Eq. (a)]. Partial reduction of the cycloalkynes provides stereoselective Z-configured cycloalkenes, which are currently inaccessible by conventional alkene metathesis.

  DOI：

  10.1002/(sici)1521-3773(19980703)37:12<1734::aid-anie1734>3.0.co;2-6

文献信息

• Ring-Closing Metathesis of Functionalized Acetylene Derivatives: A New Entry into Cycloalkynes
  作者：Alois Fürstner、Günter Seidel

  DOI：10.1002/(sici)1521-3773(19980703)37:12<1734::aid-anie1734>3.0.co;2-6

  日期：1998.7.3

  A tungsten alkylidyne catalyst is the key to achieving ring-closing metatheses of diynes to form functionalized macrocycles [Eq. (a)]. Partial reduction of the cycloalkynes provides stereoselective Z-configured cycloalkenes, which are currently inaccessible by conventional alkene metathesis.