(3-(1,3-Dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoylamino) propanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: (3-(1,3-Dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoylamino) propanoate
• 英文别名: [[3-(1,3-dioxoisoindol-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoyl]amino] propanoate
• 化学式: C₂₃H₂₄N₂O₇
• 分子量: 440.4
• InChiKey: RKUKMEJKLRORIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-(3-ethoxy-4-methoxyphenyl)-N-hydroxy-3-phthalimidopropionamide 、 丙酸酐 在 氮气 、 乙醚 作用下， 以 乙腈 、 乙醚 为溶剂， 反应 16.0h， 以to give (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoylamino) propanoate as a white solid (2.8 g, 42%)的产率得到(3-(1,3-Dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoylamino) propanoate
  参考文献：
  名称：

  Substituted acylhydroxamic acids and method of reducing TNFalpha levels

  摘要：

  Imido和Amido取代的酰羟肟酸可以降低哺乳动物中的TNF&agr;水平并抑制磷酸二酯酶。一种典型的实施例是(3-(1,3-二氧杂-2-亚苯并吲啶-3-基)-3-(3-乙氧基-4-甲氧基苯基)丙基氨基)丙酸酯。

  公开号：

  US20040167174A1

文献信息

• Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
  申请人：CELGENE CORPORATION

  公开号：EP2036553A1

  公开（公告）日：2009-03-18

  Methods of treating, preventing, modifying and managing various types of pain are disclosed. Specific methods comprise the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or surgery, psychological or physical therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

  本文公开了治疗、预防、改变和控制各种类型疼痛的方法。具体方法包括施用选择性细胞因子抑制药物或其药学上可接受的盐、溶液剂、水合物、立体异构体、凝胶体或原药，单独或与第二种活性剂和/或手术、心理或物理疗法联合使用。此外，还公开了适用于本发明方法的药物组合物、单一单位剂型和试剂盒。
• Methods of using and compositions comprising PDE4-modulators for treatment, prevention and management of tuberculosis
  申请人：CELGENE CORPORATION

  公开号：EP2818164A1

  公开（公告）日：2014-12-31

  The present invention concerns a PDE4 modulator for use in a method of treating, preventing, or managing tuberculosis, the method comprising administering to a subject a PDE4 modulator, or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, in combination with an anti-tuberculosis agent.

  本发明涉及一种用于治疗、预防或控制结核病的方法的 PDE4 调节剂，该方法包括向受试者施用 PDE4 调节剂或其药学上可接受的盐、溶液或立体异构体，并与抗结核剂结合使用。
• PDE4 modulators for treating and preventing immune reconstitution inflammatory syndrome (IRIS)
  申请人：Celgene Corporation

  公开号：US10682336B2

  公开（公告）日：2020-06-16

  Methods of treating immune reconstitution inflammatory syndrome (IRIS) in immunodeficient patients, including HIV patients, using PDE4 modulators are described.

  描述了使用 PDE4 调节剂治疗免疫缺陷患者（包括艾滋病患者）的免疫重建炎症综合征（IRIS）的方法。
• Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment and management of macular degeneration
  申请人：——

  公开号：US20040091454A1

  公开（公告）日：2004-05-13

  Methods of treating, preventing and/or managing macular degeneration are disclosed. Specific embodiments encompass the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or surgery. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

  本文公开了治疗、预防和/或控制黄斑变性的方法。具体的实施方案包括单独或与第二种活性剂和/或手术联合使用选择性细胞因子抑制药物或其药学上可接受的盐、溶液、水合物、立体异构体、凝胶体或原药。此外，还公开了适用于本发明方法的药物组合物、单一单位剂型和试剂盒。
• Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders
  申请人：Zeldis B. Jerome

  公开号：US20050142104A1

  公开（公告）日：2005-06-30

  Methods of treating, preventing and managing an asbestos-related disease or disorder are disclosed. Specific embodiments encompass the administration of a PDE4 modulator, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or chemotherapy, surgery, or radiation therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in the methods of the invention are also disclosed.

  本研究公开了治疗、预防和控制石棉相关疾病或紊乱的方法。具体的实施方案包括单独或与第二种活性剂和/或化疗、手术或放疗联合使用 PDE4 调节剂或其药学上可接受的盐、溶液剂、水合物、立体异构体、凝胶体或原药。此外，还公开了适用于本发明方法的药物组合物、单一单位剂型和试剂盒。