2-Hydroxyethyl 1-[3-[1-(2-ethoxy-2-oxoethyl)piperidin-4-yl]phenyl]benzimidazole-5-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-Hydroxyethyl 1-[3-[1-(2-ethoxy-2-oxoethyl)piperidin-4-yl]phenyl]benzimidazole-5-carboxylate
• 化学式: C₂₅H₂₉N₃O₅
• 分子量: 451.5
• InChiKey: LXIANOAYOGZXRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  93.9
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] NOVEL BENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT OF GABA-ALFA MEDIATED DISORDERS<br/>[FR] NOUVEAUX DERIVES DE BENZIMIDAZOLE POUR LE TRAITEMENT DE TROUBLES INDUITS PAR GABA-ALFA
  申请人：NEUROSEARCH AS

  公开号：WO2002050057A1

  公开（公告）日：2002-06-27

  Novel benzimidazole derivatives of the general formula (I) where the meanings of R?1 and R2¿ are as given in the claims and the description, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABA¿A? receptor complex, and in particular for inducing and maintaining anaesthesia, sedation and muscle relaxation, as well as for combating febrile convulsions in children. The compounds of the invention may also be used by veterinarians.