3-[(2-Hydroxy-3-methylbutanoyl)amino]propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[(2-Hydroxy-3-methylbutanoyl)amino]propanoic acid
• 化学式: C₈H₁₅NO₄
• 分子量: 189.21
• InChiKey: DARDVQMPKFOPRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] BIOLOGICAL FERMENTATION USING DIHYDROXYACETONE AS A SOURCE OF CARBON<br/>[FR] FERMENTATION BIOLOGIQUE UTILISANT DE LA DIHYDROXYACÉTONE COMME SOURCE DE CARBONE
  申请人：KEMBIOTIX LLC

  公开号：WO2017139420A1

  公开（公告）日：2017-08-17

  The present invention relates to the use of hydrocarbons derived from natural gas in the fermentative production of biochemicals including biofuels. More specifically, the present invention provides the method for manufacturing dihydroxyacetone ("DHA") from natural gas, biogas, biomass and CO2 released from industrial plants including electricity-generating plants, steel mills and cement factories and the use of DHA as a source of organic carbon in the fermentative production of biochemicals including biofuels. The present invention comprises three stages. In the first stage of the present invention, syngas and formaldehyde are produced from natural gas, biogas, biomass and CO2 released from industrial plants. In the second stage of the present invention, formaldehyde and syngas are condensed to produce DHA. In the third stage of the present invention, biochemicals including biofuels are produced from DHA using fermentation process involving wild type or genetically modified microbial biocatalysts.

  本发明涉及使用从天然气中提取的碳氢化合物在生物化学品，包括生物燃料的发酵生产中的应用。更具体地说，本发明提供了一种从天然气、沼气、生物质和工业厂房中释放的CO2中制造二羟基丙酮（"DHA"）的方法，以及将DHA作为有机碳源在发酵生产中制造生物化学品，包括生物燃料的应用。本发明包括三个阶段。在本发明的第一阶段中，从天然气、沼气、生物质和工业厂房中释放的CO2中产生合成气和甲醛。在本发明的第二阶段中，甲醛和合成气被凝结成DHA。在本发明的第三阶段中，使用野生型或基因改造的微生物生物催化剂进行发酵过程，从DHA中生产生物化学品，包括生物燃料。
• Semi-continuous cascade fermentation process for pantothenate production
  申请人：DSM IP Assets B.V.

  公开号：EP1918382A1

  公开（公告）日：2008-05-07

  The present invention relates to a new semi-continuous cascade system (SCCS) for the production of pantothenate by fermentation. This process provides an improved volumetric productivity and enhanced pantothenate yield. This is achieved by the new fermentation process using the semi-continuous cascade system, which comprises a setup of at least 2 fermentation tanks interconnected in a row. Fermentation is carried out in these tanks applying feeding profiles able to modulate Carbon/Nitrogen/Phosphor (C/N/P) at levels that keeps central metabolism active but allows enough C/N for production. Fermented medium transfers are performed from one tank into the next tank in an attempt to extend its biocatalitic activity for additional reaction time (Δt) before being harvested. Medium withdrawals are performed from the tanks into a separated tank and subjected to downstream operations. The medium transfers and medium withdrawals are calculated according to the present invention so that the volume in each tank remains within a set target +/- 10%. This invention also discloses that glutamate in the presence of ammonia ions improve the utilization of the N-sources.

  本发明涉及一种通过发酵生产泛酸盐的新型半连续级联系统（SCCS）。该工艺提高了容积生产率和泛酸产量。这是通过使用半连续级联系统的新发酵工艺实现的，该系统由至少 2 个相互连接的发酵罐组成。发酵在这些发酵罐中进行，采用的进料方式能够调节碳/氮/磷（C/N/P）的水平，既能保持中央代谢的活性，又能为生产提供足够的碳/氮。发酵培养基从一个培养槽转移到下一个培养槽，以延长其生物催化活性，并在收获前延长反应时间（Δt）。介质从储罐提取到一个分离的储罐，然后进行下游操作。根据本发明对培养基转移和培养基提取进行计算，使每个罐中的容积保持在设定目标 +/- 10% 的范围内。本发明还揭示了氨离子存在下的谷氨酸可提高氮源的利用率。
• Semi-continuous fermentation process for pantothenate production
  申请人：DSM IP Assets B.V.

  公开号：EP1918383A1

  公开（公告）日：2008-05-07

  The present invention relates to a new semi-continuous process (SCP) for the production of pantothenate by fermentation. This process provides an improved productivity and product concentration while the strain capability of converting glucose into pantothenate maintains stable over a long period of cultivation. The SCP enhances the pantothenate synthesis up to 41 g/I within 48 h as compared to the ~26.6 g/l achieved with the standard riboflavin process using the same strain (Bacillus subtilis, genotype P15panBCD P15panE). The semi-continuous fermentation process is based on a continuous feeding rate and a discontinuous medium withdrawal. The new semi-continuous process for the pantothenate production allows longer cultivation times of more than 140 hours for Bacillus strains without drastically diminishing specific productivities and glucose conversion efficiency.

  本发明涉及一种通过发酵生产泛酸盐的半连续新工艺（SCP）。该工艺提高了生产率和产品浓度，同时菌株将葡萄糖转化为泛酸盐的能力在长期培养过程中保持稳定。 与使用相同菌株（枯草芽孢杆菌，基因型 P15panBCD P15panE）的标准核黄素工艺的 ~26.6 克/升相比，SCP 在 48 小时内将泛酸合成量提高到 41 克/升。半连续发酵工艺基于连续的进料速度和不连续的培养基抽取。用于生产泛酸盐的新型半连续发酵工艺可使芽孢杆菌菌株的培养时间延长至 140 小时以上，而不会大幅降低特定生产率和葡萄糖转化效率。
• Method and microorganisms for the production of 3-(2-hydroxy-3-methyl-butyrylamino)-propionic acid (hmbpa)
  申请人：——

  公开号：US20040048343A1

  公开（公告）日：2004-03-11

  The present invention features methods of producting 3-(2-hydroxy-3-methyl-butyrylamino)-propionic acid (“HMBPA”) and &agr;-hydroxyisovalerate (“&agr;-HIV”) utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. Recombinant microorganisms and conditions for culturing same are also featured. Also featured are compositions including HMBPA and compositions including &agr;-HIV.

  本发明的特点是利用具有改良泛酸生物合成酶活性的微生物生产 3-(2-羟基-3-甲基丁酰氨基)-丙酸（"HMBPA"）和&agr;-羟基异戊酸（"&agr;-HIV"）的方法。此外，还介绍了重组微生物及其培养条件。此外，还介绍了包括 HMBPA 的组合物和包括 &agr;-HIV 的组合物。
• Processes for enhanced production of pantothenate
  申请人：——

  公开号：US20040086982A1

  公开（公告）日：2004-05-06

  The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features methods for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

  本发明的特点是利用具有改良泛酸盐生物合成酶活性的微生物生产泛酸盐和泛酸盐的改良方法。特别是，本发明的特点是减少副产品的形成，提高所需产品的产量和纯度。本发明还包括重组微生物及其培养条件。此外，本发明还包括由此类微生物生产的组合物。