3,5-diamino-N-[N'-[2-[2-[2-[[amino-[(3,5-diamino-6-chloropyrazine-2-carbonyl)amino]methylidene]amino]ethoxy]ethoxy]ethyl]carbamimidoyl]-6-chloropyrazine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3,5-diamino-N-[N'-[2-[2-[2-[[amino-[(3,5-diamino-6-chloropyrazine-2-carbonyl)amino]methylidene]amino]ethoxy]ethoxy]ethyl]carbamimidoyl]-6-chloropyrazine-2-carboxamide
• 化学式: C₁₈H₂₆Cl₂N₁₄O₄
• 分子量: 573.4
• InChiKey: WNIDVYQSSQLWNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  38
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  309
• 氢给体数：
  8
• 氢受体数：
  14

文献信息

• CONJUGATES OF SODIUM CHANNEL BLOCKERS AND METHODS OF USING THE SAME
  申请人：UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

  公开号：EP1196396A1

  公开（公告）日：2002-04-17
• [EN] CONJUGATES OF SODIUM CHANNEL BLOCKERS AND METHODS OF USING THE SAME<br/>[FR] CONJUGATS DE BLOQUEURS DU CANAL SODIQUE ET PROCEDES D'UTILISATION
  申请人：UNIV NORTH CAROLINA

  公开号：WO2001005773A1

  公开（公告）日：2001-01-25

  Compounds of the general formula P1-L-P2; wherein 'P1' is a pyrazinoylguanidine sodium channel blocker, 'L' is a linking group, and 'P2' is either (i) a pyrazinoylguanidine sodium channel blocker or (ii) a P2Y2 receptor agonist, are disclosed. Pharmaceutical formulations containing the same and methods of use thereof to hydrate mucosal surfaces such as airway mucosal surfaces are also disclosed.