(3R,4S)-3-methoxy-1-methylsulfanyl-4-phenylazetidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (3R,4S)-3-methoxy-1-methylsulfanyl-4-phenylazetidin-2-one
• 化学式: C₁₁H₁₃NO₂S
• 分子量: 223.29
• InChiKey: JNZHAUJHSDEZCK-VHSXEESVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  54.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• DERIVATIVE N-THIOLATED 2-OXAZOLIDINONE ANTIBIOTICS
  申请人：Turos Edward

  公开号：US20090156654A1

  公开（公告）日：2009-06-18

  This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by Ndeprotection and N-sulfenylation. These new substances were found to exhibit potent anti-bacterial activity, including bacteriostatic properties against Staphylococcus spp., including methicillin resistant Staphylococcus aureus (MRSA), and Bacillus spp., including Bacillus anthracis.
• US8703963B2
  申请人：——

  公开号：US8703963B2

  公开（公告）日：2014-04-22