4-Chloro-2-[(4-chloro-6-methoxypyrimidin-2-yl)disulfanyl]-6-methoxypyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Chloro-2-[(4-chloro-6-methoxypyrimidin-2-yl)disulfanyl]-6-methoxypyrimidine
• 化学式: C₁₀H₈Cl₂N₄O₂S₂
• 分子量: 351.2
• InChiKey: YIGHZBMXDWTTSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  121
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] METHOD OF PRODUCING SUBSTITUTED PYRIMIDINE DERIVATIVES<br/>[FR] PROCEDE DE PRODUCTION DE DERIVES DE PYRIMIDINE SUBSTITUES
  申请人：NOVARTIS AG

  公开号：WO2000046212A1

  公开（公告）日：2000-08-10

  Method of producing 4-chloropyrimidine derivatives of formula (I) wherein, R1 is chlorine, CH3S- or a radical (a); and R2 is chlorine or CH3O- by chlorination of a compound of formula (II), wherein R3 signifies OH or CH3O-; and R4 signifies OH, CH3S- or SH, in the presence of an inert solvent and at least one catalyst, as well as the use of these compounds of formula (I) in the production of 7[(4,6-dimethoxy-pyrimidin-2-yl)thio]-3-methylphthalide.