2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4 (5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4 (5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine
• 英文别名: [1-(7,8-dimethoxy-4,10-dioxo-5H-triazolo[4,5-c][1]benzazepin-2-yl)-2-methylpropyl] propan-2-yl carbonate
• 化学式: C₂₀H₂₄N₄O₇
• 分子量: 432.433
• InChiKey: OPONDCCCAYHDBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  131
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents
  申请人：Ohtsuka Yasuo

  公开号：US20060074074A1

  公开（公告）日：2006-04-06

  Tricyclic triazolobenzazepine derivatives in the form or a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereon. The compounds are useful as antiallergic agents and exhibit excellent bioavailability. wherein R 1 represents hydrogen, OH, alkyl or phenyl alkyl, R 2 , R 3 , R 4 , and R 5 represent hydrogen, halogen, optionally protected hydroxyl, formyl, optionally substituted alkyl, alkenyl, alkoxy or the like, and Q represents a group selected from the following groups (i) to (iv), halogen, or alkoxy:

  本发明提供了三环三唑苯并氮杂蒽衍生物的前药形式。根据本发明，所述化合物为公式（I）所表示的化合物及其药理学上可接受的盐和溶剂化物。该化合物可用作抗过敏药物，且具有优异的生物利用度。其中R1代表氢、OH、烷基或苯基烷基，R2、R3、R4和R5代表氢、卤素、可选保护的羟基、甲酰基、可选取代的烷基、烯基、烷氧基或类似基团，Q代表以下基团（i）至（iv）、卤素或烷氧基中的一种。
• TRICYCLIC TRIAZOLOBENZAZEPINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND ANTIALLERGIC
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1026167A1

  公开（公告）日：2000-08-09

  Tricyclic triazolobenzazepine derivatives in the form of a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereof. The compounds are useful as antiallergic agents and exhibit excellent bioavailability. wherein R1 represents hydrogen, OH, alkyl or phenyl alkyl, R2, R3, R4, and R5 represent hydrogen, halogen, optionally protected hydroxyl, formyl, optionally substituted alkyl, alkenyl, alkoxy or the like, and Q represents a group selected from the following groups (i) to (iv), halogen, or alkoxy:

  本发明提供了原药形式的三环三唑并氮杂卓衍生物。根据本发明的化合物是由式（I）代表的化合物及其药理学上可接受的盐和溶液。这些化合物可用作抗过敏剂，并具有良好的生物利用度。 其中 R1 代表氢、OH、烷基或苯基烷基、 R2、R3、R4 和 R5 代表氢、卤素、任选保护的羟基、甲酰基、任选取代的烷基、烯基、烷氧基或类似物，以及 Q 代表选自以下基团 (i) 至 (iv)、卤素或烷氧基：
• AMORPHOUS SUBSTANCE OF TRICYCLIC TRIAZOLOBENZAZEPINE DERIVATIVE
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1466914A1

  公开（公告）日：2004-10-13

  Disclosed are 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine, which has been rendered amorphous and possesses improved absorption and dissoluvability, and a pharmaceutical composition comprising the same. Also disclosed are processes for producing 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine, which has been rendered amorphous, and a pharmaceutical composition comprising the same.

  本发明公开了 2-(1-异丙氧基羰基氧基-2-甲基丙基)-7,8-二甲氧基-4(5H),10-二氧代-2H-1,2,3-三唑并[4,5-c][1]苯并氮杂卓，该化合物已变为无定形，具有更好的吸收性和溶解性，以及包含该化合物的药物组合物。此外，还公开了生产 2-(1-异丙氧基羰基氧基-2-甲基丙基)-7,8-二甲氧基-4(5H),10-二氧代-2H-1,2,3-三唑并[4,5-c][1]苯并氮杂卓的工艺，该工艺已将苯并氮杂卓变为无定形，并公开了包含该工艺的药物组合物。
• PROPHYLACTIC OR THERAPEUTIC AGENT FOR ALLERGIC OPHTHALMIC DISEASE OR ALLERGIC NASAL DISEASE COMPRISING TRICYCLIC TRIAZOLOBENZOAZEPINE DERIVATIVE
  申请人：Meiji Seika Kaisha Ltd.

  公开号：EP1994931A1

  公开（公告）日：2008-11-26

  The present invention provides a pharmaceutical composition for use in the prophylaxis or treatment of allergic ophthalmic diseases or allergic nasal diseases, which comprises 7,8-dimethoxy-4(5H),10-dioxo-1H-1,2,3-triazolo[4,5-c][1] benzazepine, 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5 H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1] benzazepine or a pharmaceutically acceptable salt thereof. The pharmaceutical composition according to the present invention has few side effects, exerts strong prophylactic and therapeutic effects in the late phase exhibiting pharmaceutical resistance to conventional instillations, and can be used appropriately for topical applications.

  本发明提供了一种用于预防或治疗过敏性眼病或过敏性鼻病的药物组合物，该组合物包括7,8-二甲氧基-4(5H)、10-二氧代-1H-1,2,3-三唑并[4,5-c][1]苯并氮杂卓、2-(1-异丙氧基羰氧基-2-甲基丙基)-7,8-二甲氧基-4(5H),10-二氧代-2H-1,2,3-三唑并[4,5-c][1]苯并氮杂卓或其药学上可接受的盐。本发明的药物组合物副作用小，在后期阶段具有很强的预防和治疗效果，对传统的灌注具有药物抵抗力，可适当用于局部应用。
• PREVENTIVE OR THERAPEUTIC AGENT FOR INFLAMMATORY BOWEL DISEASE
  申请人：Meiji Seika Kaisha Ltd.

  公开号：EP2123277A1

  公开（公告）日：2009-11-25

  The present invention relates to a pharmaceutical composition for preventing or treating inflammatory bowel diseases, which comprises 7,8-dimethoxy-4(5H),10-dioxo-1H-1,2,3-triazolo[4,5-c][1]benzo azepine, a prodrug thereof, preferably 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5 H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzoazepine as a prodrug, or a pharmaceutically acceptable salt thereof. The pharmaceutical composition according to the present invention is effective in the prophylaxis and therapy of the inflammatory bowel diseases and has few side effects. Particularly, the pharmaceutical composition according to the present invention may exhibit strong prophylactic and therapeutic effects even on severe cases having resistance to the conventional therapeutics.

  本发明涉及一种用于预防或治疗炎症性肠病的药物组合物，它包括 7,8-二甲氧基-4(5H),10-二氧代-1H-1,2,3-三唑并[4,5-c][1]苯并氮杂卓、其原药，优选 2-(1-异丙氧基羰基氧基-2-甲基丙基)-7,8-二甲氧基-4(5H),10-二氧代-2H-1,2,3-三唑并[4,5-c][1]苯并氮杂卓原药，或其药学上可接受的盐。根据本发明的药物组合物对预防和治疗炎症性肠病有效，且副作用小。特别是，根据本发明的药物组合物即使对传统疗法有抗药性的严重病例也能显示出很强的预防和治疗效果。