6-[[4-(2,6-Dimethylmorpholin-4-yl)sulfonylphenyl]methyl]-4-(trifluoromethyl)chromen-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 6-[[4-(2,6-Dimethylmorpholin-4-yl)sulfonylphenyl]methyl]-4-(trifluoromethyl)chromen-2-one
• 化学式: C₂₃H₂₂F₃NO₅S
• 分子量: 481.5
• InChiKey: UATXXGBIZYIVPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  81.3
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• Androgen receptor antagonists
  申请人：Du Y. Daniel

  公开号：US20050085466A1

  公开（公告）日：2005-04-21

  The present invention is directed to a new class of 6-sulfonamido-quinolin-2-one and 6-sulfonamido-2-oxo-chromene derivatives to their use as androgen antagonists, and to relieve conditions associated with inappropriate activation of the androgen receptor.

  本发明涉及一种新型的6-磺酰胺基喹啉-2-酮和6-磺酰胺基-2-氧代色烯衍生物，用作雄激素受体拮抗剂，并用于缓解与雄激素受体不适当激活相关的病症。
• ANDROGEN RECEPTOR ANTAGONISTS
  申请人：Warner-Lambert Company LLC

  公开号：EP1587509A2

  公开（公告）日：2005-10-26
• US7057048B2
  申请人：——

  公开号：US7057048B2

  公开（公告）日：2006-06-06
• [EN] ANDROGEN RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DE RECEPTEURS D'ANDROGENES
  申请人：WARNER LAMBERT CO

  公开号：WO2004065539A2

  公开（公告）日：2004-08-05

  The present invention is directed to a new class of 6-sulfonamido-quinolin-2-one and 6­-sulfonamido-2-oxo-chromene derivatives to their use as androgen antagonists, and to relieve conditions associated with inappropriate activation of the androgen receptor. These compounds may be represented by the formula (I), in which; M is NZ or O; A is represented by -S(62): %3.