(6R,7R)-7-[[2-[5-(2-amino-2-oxoethoxy)-2-[(E)-methoxyiminomethyl]phenoxy]acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (6R,7R)-7-[[2-[5-(2-amino-2-oxoethoxy)-2-[(E)-methoxyiminomethyl]phenoxy]acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 化学式: C₂₂H₂₄N₈O₈S₂
• 分子量: 592.613
• InChiKey: QOZLFKNCQVETFE-QJFLDHDHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  40
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  264
• 氢给体数：
  3
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  (E)-(5-aminocarbonylmethyleneoxy-2-methoxyiminomethylphenoxy)acetic acid 在 N-甲基吗啉 、 水 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 (6R,7R)-7-[[2-[5-(2-amino-2-oxoethoxy)-2-[(E)-methoxyiminomethyl]phenoxy]acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  参考文献：
  名称：

  Synthesis and activity of cephalosporins containing an oxyiminomethylene functionality in the ortho-position of a phenyl- or phenoxyacetic acid C-7 side chain substituent

  摘要：

  A new series of cephalosporins having in the C-7 side chain a phenyl- or a phenoxyacetamido group bearing an oxyiminomethyl function in the ortho-position of the aromatic ring was prepared. Their in vitro activity was tested against both Gram+ and Gram- strains. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(98)00112-8

文献信息

• Synthesis and activity of cephalosporins containing an oxyiminomethylene functionality in the ortho-position of a phenyl- or phenoxyacetic acid C-7 side chain substituent
  作者：Domenico Albanese、Dario Landini、Mario Leone、Michele Penso、Maurizio Zenoni

  DOI：10.1016/s0014-827x(98)00112-8

  日期：1998.11

  A new series of cephalosporins having in the C-7 side chain a phenyl- or a phenoxyacetamido group bearing an oxyiminomethyl function in the ortho-position of the aromatic ring was prepared. Their in vitro activity was tested against both Gram+ and Gram- strains. (C) 1998 Elsevier Science S.A. All rights reserved.