(4-Methyl-2-oxochromen-7-yl)oxymethyl hydrogen sulfate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: (4-Methyl-2-oxochromen-7-yl)oxymethyl hydrogen sulfate
• 化学式: C₁₁H₁₀O₇S
• 分子量: 286.26
• InChiKey: HCDDMJMTAFVVAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Energy transfer hybridization assay using intercalators and lanthanide metals
  申请人：Enzo Diagnostics, Inc.,

  公开号：US20010026921A1

  公开（公告）日：2001-10-04

  Disclosed is a nucleic acid hybridization assay composition for detecting the presence or absence of a target oligo- or polynucleotide in a sample. The composition comprises: a solid matrix having at least one surface which is substituted with a first intercalator capable of binding dsDNA, dsRNA, or DNA-RNA hybrids; a second intercalator, which may or may not comprise at least one fluorophore, said intercalator or said fluorophore, each acting as either an energy donor or an energy acceptor: and an oligo- or polynucleotide probe which is specifically hybridizable with the target oligo- or polynucleotide and has directly or indirectly bound thereto, at least one lanthanide metal chelate or at least one fluorophore, each acting as either an energy donor or an energy acceptor. Also disclosed are a method and kit for its use.

  本发明公开了一种核酸杂交检测组合物，用于检测样品中目标寡核苷酸或多核苷酸的存在或缺失。该组合物包括：具有至少一表面被第一插入剂取代的固体基质，该第一插入剂能够结合dsDNA，dsRNA或DNA-RNA杂交物；第二插入剂，可以包含至少一个荧光团，该插入剂或该荧光团各自作为能量给体或能量受体：以及一种寡核苷酸或多核苷酸探针，该探针能够与目标寡核苷酸或多核苷酸特异性杂交，并且直接或间接地结合至少一种镧系金属螯合物或至少一种荧光团，该荧光团或螯合物各自作为能量给体或能量受体。本发明还公开了其使用的方法和试剂盒。
• US5998135A
  申请人：——

  公开号：US5998135A

  公开（公告）日：1999-12-07
• US6239271B1
  申请人：——

  公开号：US6239271B1

  公开（公告）日：2001-05-29