(Benzylamino)carbonylphosphonic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Benzylamino)carbonylphosphonic acid
• 英文别名: benzylcarbamoylphosphonic acid
• 化学式: C₈H₁₀NO₄P
• 分子量: 215.145
• InChiKey: ZQPCSYKQYDZVKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯乙腈 在 t-butylphosphite bound on the Wang resin A 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三氟乙酸 作用下， 以 乙腈 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 (Benzylamino)carbonylphosphonic acid
  参考文献：
  名称：

  Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein

  摘要：

  Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Sre SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00140-3

文献信息

• Amide derivatives of phosphonoformic acid, pharmaceutical compositions and methods for combating virus infections
  申请人：Astra Läkemedel Aktiebolag

  公开号：EP0003008A1

  公开（公告）日：1979-07-11

  A pharmaceutical preparation containing as active ingredient a compound of the formula wherein R, and R2, which are the same or different, each is selected from the group consisting of hydrogen. alkyl groups containing 1-6 carbon atoms; cycloalkyl groups containing 3-6 carbon atoms; cycloalkyl-alkyl groups containing 4-6 carbon atoms; phenyl; benzyl, and wherein R, and R5 are the same or different, and each are selected from the group consisting of hydrogen, alkyl groups containing 1-6 carbon atoms, cycloalkyl groups containing 4-6 carbon atoms, phenyl, and benzyl; or R, and R5 together with the nitrogen atom may form a pyrrolidine or piperidine ring: or a physiologically acceptable salt or an optical isomer thereof: novel compounds within formula I, methods for their preparation and their medicinal use.

  一种药物制剂，其活性成分为如下式的化合物 其中R和R2相同或不同，各自选自由氢组成的组。含 1-6 个碳原子的烷基；含 3-6 个碳原子的环烷基；含 4-6 个碳原子的环烷基-烷基；苯基；苄基，其中 R 和 R5 相同或不同，且各自选自由氢、含 1-6 个碳原子的烷基、含 4-6 个碳原子的环烷基、苯基和苄基组成的组；或 R 和 R5 与氮原子一起可形成吡咯烷或哌啶环：或其生理上可接受的盐或光学异构体：式 I 中的新型化合物、其制备方法及其药用用途。
• Plant-growth-regulating<i>N</i>-(phosphonoacetyl)amines
  作者：Piotr Wieczorek、Dorota Miliszkiewicz、Barbara Lejczak、Miroslaw Soroka、Pawel Kafarski

  DOI：10.1002/ps.2780400110

  日期：1994.1

  AbstractA series of N‐(phosphonacetyl)amine derivatives were synthesized and screened for plant‐growth regulating activity on Lepidium sativum L. and Cucumis sativus L. Aromatic N‐(phosphonoacetyl)amines. which may be considered as possible analogues of N‐acylaniline herbicides obtained by replacement of their acyl group by the phosphonacetyl moiety, exhibited significant or moderate herbicidal activity. In contrast, N‐(phosphonoacetyl)amino acids and N‐(phosphonoacetyl)aminophosphonic acids promoted the growth of L. sativum and C. sativus roots.
• US7468359B2
  申请人：——

  公开号：US7468359B2

  公开（公告）日：2008-12-23