6-(Cyclopropylmethyl)-8-(3-nitrophenyl)pyrido[2,3-d]pyridazin-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(Cyclopropylmethyl)-8-(3-nitrophenyl)pyrido[2,3-d]pyridazin-5-one
• 化学式: C17H14N4O3
• 分子量: 322.32
• InChiKey: CWIIRPBVDWSZJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  91.4
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist
  申请人：Nycomed GmbH

  公开号：EP1849468A2

  公开（公告）日：2007-10-31

  The invention relates to the combined administration of PDE4 or PDE3/4 inhibitors and histamine receptor antagonists for the treatment of respiratory diseases.

  本发明涉及联合使用 PDE4 或 PDE3/4 抑制剂和组胺受体拮抗剂治疗呼吸系统疾病。
• Synergistic combination
  申请人：Nycomed GmbH

  公开号：EP2193808A1

  公开（公告）日：2010-06-09

  The invention relates to the combined administration of PDE inhibitors and β2 adrenoceptor agonists for the treatment of respiratory tract disorders.

  本发明涉及联合使用 PDE 抑制剂和 β2 肾上腺素受体激动剂治疗呼吸道疾病。
• ADMINISTRATION OF PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF PREMATURE EJACULATION
  申请人：Vivus, Inc.

  公开号：EP1418896A2

  公开（公告）日：2004-05-19
• Composition for regenerative treatment of cartilage disease
  申请人：Takigawa Masaharu

  公开号：US20070155652A1

  公开（公告）日：2007-07-05

  A composition for regenerative treatment of cartilage disease, which comprises a PDE4 inhibitor as an active ingredient, specifically a composition comprising a PDE4 inhibitor and a biocompatible and biodegradable polymer is provided, which composition, when formulated into a form suited to administer locally to affected cartilage region, such as microsphere preparation, can provide a pharmaceutical composition showing an excellent effect in regenerative treatment of cartilage.
• Composition for accelerating bone fracture healing
  申请人：Sakurai Naoki

  公开号：US20080031958A1

  公开（公告）日：2008-02-07

  A composition for accelerating fracture healing, which has a PDE4 inhibitor as an active ingredient, specifically a composition having a PDE4 inhibitor and a biocompatible and biodegradable polymer is provided, which composition, when formulated into a form suitable for local administration such as a microsphere preparation, can provide a pharmaceutical composition showing an excellent effect in the early healing of bone fracture. The composition is useful in healing of refractory fracture of elderly people and diabetic or osteoporosis patients.