1-(2-ethoxyethyl)-3-methyl-5-[(3R)-3-methylpiperazin-1-yl]-N-pyrimidin-4-yl-1H-pyrazolo-[4,3-d]pyrimidin-7-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-(2-ethoxyethyl)-3-methyl-5-[(3R)-3-methylpiperazin-1-yl]-N-pyrimidin-4-yl-1H-pyrazolo-[4,3-d]pyrimidin-7-amine
• 英文别名: 1-(2-ethoxyethyl)-3-methyl-5-[(3R)-3-methylpiperazin-1-yl]-N-pyrimidin-4-ylpyrazolo[4,3-d]pyrimidin-7-amine
• 化学式: C₁₉H₂₇N₉O
• 分子量: 397.483
• InChiKey: LRFSIFWYXRPHFG-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Novel pharmaceuticals
  申请人：Bell Simon Andrew

  公开号：US20050043325A1

  公开（公告）日：2005-02-24

  This invention relates to compounds of formula (I)

  该发明涉及式(I)的化合物。
• NOVEL PHARMACEUTICALS
  申请人：Bell Simon Andrew

  公开号：US20070270412A1

  公开（公告）日：2007-11-22

  This invention relates to compounds of formula (I)

  该发明涉及式(I)的化合物。
• 1-(1-(2-Ethoxyethyl)-3-Ethyl-7-(4-Methylpyridin-2-Ylamino)-1H-Pyrazolo[4,3-D]Pyrimidin-5-YL) Piperidine-4-Carboxylic Acid And Salts Thereof
  申请人：Tollefson Michael B.

  公开号：US20110059993A1

  公开（公告）日：2011-03-10

  The present invention comprises 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)piperidine-4-carboxylic acid and its salts. The invention further comprises pharmaceutical compositions, methods of treatment, and synthetic methods relating to 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)piperidine-4-carboxylic acid and its salts.

  本发明涉及1-(1-(2-乙氧基乙基)-3-乙基-7-(4-甲基吡啶-2-基氨基)-1H-吡唑并[4,3-d]嘧啶-5-基)哌啶-4-羧酸及其盐。该发明还涉及与1-(1-(2-乙氧基乙基)-3-乙基-7-(4-甲基吡啶-2-基氨基)-1H-吡唑并[4,3-d]嘧啶-5-基)哌啶-4-羧酸及其盐相关的药物组合物、治疗方法和合成方法。
• 1-(1- (2-Ethoxyethyl)-3-Ethyl-7-(4-Methylpyridin-2-Ylamino) - 1H-Pyrazolo [4,3-D] Pyrimidin-5-YL) Piperidine-4-Carboxylic acid and salts thereof
  申请人：Tollefson Michael B.

  公开号：US20090156618A1

  公开（公告）日：2009-06-18

  The present invention comprises 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)piperidine-4-carboxylic acid and its salts. The invention further comprises pharmaceutical compositions, methods of treatment, and synthetic methods relating to 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)piperidine-4-carboxylic acid and its salts.

  本发明涉及1-(1-(2-乙氧乙基)-3-乙基-7-(4-甲基吡啶-2-基氨基)-1H-吡唑并[4,3-d]嘧啶-5-基)哌啶-4-羧酸及其盐。本发明还涉及与1-(1-(2-乙氧乙基)-3-乙基-7-(4-甲基吡啶-2-基氨基)-1H-吡唑并[4,3-d]嘧啶-5-基)哌啶-4-羧酸及其盐相关的药物组合物、治疗方法和合成方法。
• 5,7-DIAMINOPYRAZOLO¬4,3-D PYRIMIDINES USEFUL IN THE TRAETMENT OF HYPERTENSION
  申请人：Pfizer Limited

  公开号：EP1620437B1

  公开（公告）日：2009-06-17