N-[5-(2-methoxyphenoxy)-6-(oxolan-2-ylmethoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-propan-2-ylpyridine-2-sulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-[5-(2-methoxyphenoxy)-6-(oxolan-2-ylmethoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-propan-2-ylpyridine-2-sulfonamide
• 化学式: C₃₀H₃₁N₉O₆S
• 分子量: 645.7
• InChiKey: RUNVEINSQUGOFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  46
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  198
• 氢给体数：
  2
• 氢受体数：
  14

文献信息

• [EN] SUBSTITUTED SULFONYLAMINOPYRIMIDINES<br/>[FR] SULFONYLAMINOPYRIMIDINES SUBSTITUEES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2001081338A1

  公开（公告）日：2001-11-01

  The present invention relates to novel substituted pyrimidines of the general formula I and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of the general formula (I) and especially their use as endothelin receptor antagonists.