4,5-bistrifluoromethyl-10-aza-tricyclo[6.3.0(2,7)]dodeca-2(7),3,5-triene | 357424-31-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 4,5-bistrifluoromethyl-10-aza-tricyclo[6.3.0(2,7)]dodeca-2(7),3,5-triene
• 英文别名: 4,5-bistrifluoromethyl-10-aza-tricyclo[6.3.1.0.2.7]dodeca-2(7),3,5-triene；4,5-bistrifluoromethyl-10-aza-tricyclo[6.3.1.0^2.7]dodeca-2,4,6-triene；4,5-Bis(trifluoromethyl)-10-azatricyclo[6.3.1.02,7]dodeca-2,4,6-triene
• CAS: 357424-31-8
• 化学式: C₁₃H₁₁F₆N
• 分子量: 295.227
• InChiKey: JANUESOOKNBMPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] IMPROVED PROCESS FOR THE PREPARATION OF 1,3-SUBSTITUTED INDENES<br/>[FR] PROCEDE AMELIORE POUR LA PREPARATION D'INDENES 1,3-SUBSTITUTEES
  申请人：PFIZER PROD INC

  公开号：WO2004048318A1

  公开（公告）日：2004-06-10

  An improved process for the preparation of 1,3 substituted indenes which are useful intermediates in the synthesis of aryl fused azapolycyclic compounds as agents for the treatment of neurological and psychological disorders.

  一种改进的制备1,3取代茚烯的过程，这些化合物在合成芳基融合的氮杂多环化合物中起中间体作用，用作治疗神经和心理疾病的药物。
• [EN] A METHOD FOR PREPARING INDAN-1,3-DICARBOXYLIC ACID<br/>[FR] PROCEDE DE PREPARATION D'ACIDE INDAN-1,3-DICARBOXYLIQUE
  申请人：PFIZER PROD INC

  公开号：WO2004046077A1

  公开（公告）日：2004-06-03

  A method for preparing indan-1,3-dicarboxylic acid compounds which are useful intermediates in the syntheses of aryl fused azapolycyclic compounds as agents for the treatment of neurological and psychological disorders.

  一种制备对治疗神经和心理疾病有益的芳基融合氮杂多环化合物的中间体indan-1,3-二羧酸的方法。
• Process for the preparation of 1,3-substituted indenes
  申请人：Handfield Eugene Robert

  公开号：US20050004379A1

  公开（公告）日：2005-01-06

  An improved process for the preparation of 1,3 substituted indenes which are useful intermediates in the synthesis of aryl fused azapolycyclic compounds as agents for the treatment of neurological and psychological disorders.

  一种改进的制备1,3取代茚烯的工艺，该化合物是合成芳香环并氮杂多环化合物的中间体，作为治疗神经和心理障碍的药物。
• Aryl fused azapolycyclic compounds
  申请人：——

  公开号：US20030130260A1

  公开（公告）日：2003-07-10

  This invention is directed to compounds of the formula (I): 1 and their pharmaceutically acceptable salts, wherein R 1 , R 2 , and R 3 are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such compounds; and methods of using such compounds in the treatment of neurological and psychological disorders.

  本发明涉及式(I)的化合物及其药学上可接受的盐，其中R1、R2和R3如本文所定义；用于合成此类化合物的中间体，含有此类化合物的药物组合物；以及使用此类化合物治疗神经和心理疾病的方法。
• Process for the preparation of aryl fused polycyclic lactams
  申请人：Handfield Jr Eugene Robert

  公开号：US20070066827A1

  公开（公告）日：2007-03-22

  A process for the preparation of aryl fused polycyclic lactams which are useful intermediates in the synthesis of aryl fused azapolycyclic compounds as agents for the treatment of neurological and psychological disorders.

  一种制备芳基融合多环内酰胺的方法，这些化合物是合成芳基融合氮杂多环化合物的有用中间体，可以用作治疗神经和心理障碍的药物。