US10851082, Nucc-0125594

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: US10851082, Nucc-0125594
• 英文别名: 4-[[4-(benzimidazol-1-yl)pyrimidin-2-yl]amino]benzamide
• 化学式: C₁₈H₁₄N₆O
• 分子量: 330.349
• InChiKey: KAZFNRNYKKXSJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  98.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (MNK1) and 2 (MNK2)
  申请人：Northwestern University

  公开号：US10851082B2

  公开（公告）日：2020-12-01

  Disclosed are substituted aromatic N-heterocyclic compounds. The disclosed compounds typically exhibit kinase inhibition activity, for example, and inhibit Mnk1 kinase and/or Mnk2 kinase. The disclosed compounds may be used in pharmaceutical compositions and methods for treating diseases or disorders associated with Mnk1 kinase activity and/or Mnk2 kinase activity, such as cancers, diabetes, autism, and fragile X syndrome.

  所公开的是取代芳香族 N-杂环化合物。所公开的化合物通常具有激酶抑制活性，例如，可抑制 Mnk1 激酶和/或 Mnk2 激酶。所公开的化合物可用于治疗与 Mnk1 激酶活性和/或 Mnk2 激酶活性相关的疾病或紊乱的药物组合物和方法，如癌症、糖尿病、自闭症和脆性 X 综合征。
• SUBSTITUTED AROMATIC N-HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE INTERACTING KINASE 1 (MNK1) AND 2 (MNK2)
  申请人：Northwestern University

  公开号：US20170121326A1

  公开（公告）日：2017-05-04

  Disclosed are substituted aromatic N-heterocyclic compounds. The disclosed compounds typically exhibit kinase inhibition activity, for example, and inhibit Mnk1 kinase and/or Mnk2 kinase. The disclosed compounds may be used in pharmaceutical compositions and methods for treating diseases or disorders associated with Mnk1 kinase activity and/or Mnk2 kinase activity, such as cancers, diabetes, autism, and fragile X syndrome.
• US7282504B2
  申请人：——

  公开号：US7282504B2

  公开（公告）日：2007-10-16