4-(4-Fluorophenyl)-2-methyl-6-(5-piperidin-1-ylpentoxy)pyrimidine;hydrate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-(4-Fluorophenyl)-2-methyl-6-(5-piperidin-1-ylpentoxy)pyrimidine;hydrate
• 化学式: C21H30FN3O2
• 分子量: 375.5
• InChiKey: BITAXAHLKDUMHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  39.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Method for preventing or treating neurologic damage after spinal cord injury
  申请人：Kazui Teruhisa

  公开号：US20070021451A1

  公开（公告）日：2007-01-25

  The present invention provides a method for preventing and/or treating neurologic damage after spinal cord injury in a mammal including human in need thereof which comprises administering an effective amount of a compound of the general formula [I]: or a salt, or a solvate thereof, and a use thereof.

  本发明提供了一种预防和/或治疗哺乳动物，包括需要的人类，在脊髓损伤后神经损伤的方法，其包括给予一定量的一般式[I]的化合物或其盐、溶剂化物的有效量，以及其用途。
• PROCESS FOR PRODUCING PYRIMIDINE DERIVATIVE AND INTERMEDIATE THEREOF
  申请人：Nippon Shinyaku Co., Ltd.

  公开号：EP1318146B1

  公开（公告）日：2005-02-23
• Process for producing pyrimidine derivative and intermediate thereof
  申请人：——

  公开号：US20040023985A1

  公开（公告）日：2004-02-05

  The present invention relates to a method for producing a pyrimidine derivative useful as a neurocyte necrosis inhibitor and an intermediate thereof. More particularly speaking, a method for producing an acid salt of 4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine comprising reacting 4-chloro-6-(4-fluorophenyl)-2-methylpyrimidine with 5-piperidino-1-pentanol, hydrating the thus obtained 4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine and then converting the resultant hydrate into an acid salt; the hydrate as described above; and a method for producing the hydrate. According to the method of the present invention, a highly pure acid salt of 4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine can be readily and efficiently produced without using a column chromatography. Thus, this method is suitable for the production thereof on an industrial scale.
• US7091206B2
  申请人：——

  公开号：US7091206B2

  公开（公告）日：2006-08-15