5-chloro-6-(2-chloro-6-fluorophenyl)-N-(2,2,2-trifluoroethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-chloro-6-(2-chloro-6-fluorophenyl)-N-(2,2,2-trifluoroethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
• 英文别名: 5-chloro-6-(2-chloro-6-fluorophenyl)-7-(2,2,2-trifluoroethylamino)-[1,2,4]triazolo[1,5-a]pyrimidine；5-chloro-6-(2-chloro-6-fluorophenyl)-N-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
• 化学式: C₁₃H₇Cl₂F₄N₅
• 分子量: 380.132
• InChiKey: QJCBRGBHFJWHAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  55.1
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Substituted-triazolopyrimidines as anticancer agents
  申请人：American Home Products Corporation

  公开号：US20020068744A1

  公开（公告）日：2002-06-06

  The invention provides a method of treating or inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof and further provides a method of treating or inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof by interacting with tubulin and microtubules and promoting microtubule polymerization which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof.

  该发明提供了一种治疗或抑制哺乳动物体内癌症肿瘤细胞及相关疾病的方法，包括向该哺乳动物体内施用有效量的取代三唑吡啶衍生物或其药学上可接受的盐，并进一步提供了一种通过与微管蛋白和微管相互作用并促进微管聚合的方法，治疗或抑制哺乳动物体内癌症肿瘤细胞及相关疾病，包括向该哺乳动物体内施用有效量的取代三唑吡啶衍生物或其药学上可接受的盐。
• Fungicidal mixtures
  申请人：American Cyanamid Company

  公开号：EP0988790A1

  公开（公告）日：2000-03-29

  Fungicidal compositions comprising an acceptable carrier and/or surface active agent and synergistically effective amounts of (a) at least one azolopyrimidine of formula I in which R1, R2, L1, L2 and L3 have the meaning given in claim 1; and (b) at least one fungicidal active ingredient selected from benomyl, carboxin, captan, chlorothalonil, copper oxychloride, cyprodinil, dimethomorph, dithianon, dodine, famoxadone, fenhexamid, fenpiclonil, fenpropimorph, fluazinam, mancozeb, metalaxyl, pyrimethanil, quinoxifen, sulfur, triforine, vinclozolin, a fungicidal triazole derivative, and a synthetic strobilurine derivative. The invention also provides a method of controlling the growth of phytopathogenic fungi at a locus by applying synergistically effective amounts of at least one azolopyrimidine of formula I and at least one fungicidal active ingredient (b) to the locus.

  杀菌组合物，包括可接受的载体和/或表面活性剂以及协同有效量的以下物质 (a) 至少一种式 I 的偶氮嘧啶 其中 R1、R2、L1、L2 和 L3 具有权利要求 1 所述含义；以及 (b) 至少一种杀菌活性成分，选自苯菌灵、虫螨腈、克菌丹、百菌清、氧氯化铜、霜脲氰、二甲吗啉、噻虫嗪、多丁、霜脲氰、苯醚甲环唑、苯醚甲环唑、苯醚甲环唑、苯醚甲环唑、苯醚甲环唑、苯醚甲环唑、苯醚甲环唑、苯醚甲环唑、苯醚甲环唑、苯醚甲环唑fenpiclonil、fenpropimorph、fluazinam、mancozeb、metalaxyl、pyrimethanil、quinoxifen、sulfur、triforine、vinclozolin、一种杀真菌的三唑衍生物，以及一种合成的strobilurine衍生物。本发明还提供了一种控制植物病原真菌在基因座上生长的方法，即在基因座上施用至少一种式 I 的唑嘧啶和至少一种杀真菌活性成分 (b) 的协同有效量。
• FUNGICIDAL TRIFLUOROMETHYLALKYLAMINO-TRIAZOLOPYRIMIDINES
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0975635A1

  公开（公告）日：2000-02-02
• NON-AQUEOUS SUSPENSION CONCENTRATE
  申请人：BASF AKTIENGESELLSCHAFT

  公开号：EP1130962A1

  公开（公告）日：2001-09-12
• SUBSTITUTED-TRIAZOLOPYRIMIDINES AS ANTICANCER AGENTS
  申请人：Wyeth

  公开号：EP1307200A2

  公开（公告）日：2003-05-07