2-((3-methyl-4-(2-(2-(2-methoxyethoxy)ethoxy)ethylthio)-pyridin-2-yl)-methylthio)-1H-benzimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-((3-methyl-4-(2-(2-(2-methoxyethoxy)ethoxy)ethylthio)-pyridin-2-yl)-methylthio)-1H-benzimidazole
• 英文别名: 2-((3-methyl-4-(2-(2-(2-methoxyethoxy)ethoxy)ethylthio)-2-pyridyl) methylthio)-1H-benzimidazole；2-[[4-[2-[2-(2-methoxyethoxy)ethoxy]ethylsulfanyl]-3-methylpyridin-2-yl]methylsulfanyl]-1H-benzimidazole
• 化学式: C₂₁H₂₇N₃O₃S₂
• 分子量: 433.596
• InChiKey: ZTCKVDOQCJATJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  29
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  120
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• PYRIDINE COMPOUND AND MEDICINAL USE THEREOF
  申请人：YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.

  公开号：EP0729957A1

  公开（公告）日：1996-09-04

  A pyridine compound represented by general formula (I) or a medicinally acceptable salt thereof, and a medicinal use thereof. In said formula (I) R1 represents hydrogen, halogen, alkyl, alkoxy, hydroxy, alkoxycarbonyl, carboxy or haloalkyl; R2 and R3 represent each independently hydrogen, halogen or alkyl; R4 represents hydrogen, alkoxycarbonyl, hydroxyalkyl or acyloxyalkyl; R5 represents hydrogen or alkyl; X represents oxygen, sulfur, SO or SO2; Y and Z represent each independently CH or N; L represents ethylene or vinylene; m represents 0, 1 or 2; and n represents an integer of 1 to 1,000; provided that n represents 1 when L is vinylene and that n represents an integer of 4 to 1,000 when R4 is hydrogen, X is oxygen and L is ethylene. The compound and medicinally acceptable salts thereof are useful as medicines because they have an antiulcer effect, the effect of protecting gastro-intestinal cells, the effect of preventing recrudescence and recurrence of ulcer, and an antibacterial effect on Helicobacter pylori.

  一种由通式（I）代表的吡啶化合物或其药用盐及其药用方法。在所述式（I）中，R1 代表氢、卤素、烷基、烷氧基、羟基、烷氧基羰基、羧基或卤代烷基；R2 和 R3 各自独立地代表氢、卤素或烷基；R4 代表氢、烷氧基羰基、羟基烷基或酰氧基烷基；R5 代表氢或烷基；X 代表氧、硫、SO 或 SO2；Y和Z各自独立地代表CH或N；L代表乙烯或乙烯基；m代表0、1或2；n代表1至1,000的整数；当L为乙烯基时，n代表1；当R4为氢、X为氧和L为乙烯基时，n代表4至1,000的整数。该化合物及其药用盐具有抗溃疡作用、保护胃肠细胞的作用、防止溃疡复发的作用以及对幽门螺旋杆菌的抗菌作用，因此可用作药物。
• US5504082A
  申请人：——

  公开号：US5504082A

  公开（公告）日：1996-04-02
• US5616581A
  申请人：——

  公开号：US5616581A

  公开（公告）日：1997-04-01