5-Cyano-4-methyl-2-oxo-6-thiophen-2-yl-3,6-dihydro-2H-pyrimidine-1-carboxylic acid ethyl ester | 464192-19-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-Cyano-4-methyl-2-oxo-6-thiophen-2-yl-3,6-dihydro-2H-pyrimidine-1-carboxylic acid ethyl ester
• 英文别名: Ethyl 5-cyano-6-methyl-2-oxo-4-thiophen-2-yl-1,4-dihydropyrimidine-3-carboxylate
• CAS: 464192-19-6
• 化学式: C₁₃H₁₃N₃O₃S
• 分子量: 291.331
• InChiKey: YAZBGDORPCTELQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Cyano-substituted dihydropyrimidine compounds and their use to treat diseases
  申请人：——

  公开号：US20020143026A1

  公开（公告）日：2002-10-03

  The present invention provides compounds of formula I 1 and pharmaceutically acceptable salts thereof. The formula I compounds induce mitotic arrest thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inducing mitotic arrest.

  本发明提供了I式化合物及其药用可接受的盐。公式I化合物诱导有丝分裂停滞，因此使它们可用作抗癌剂。公式I化合物还可用于治疗其他可以通过诱导有丝分裂停滞来治疗的疾病。
• [EN] CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES<br/>[FR] COMPOSES DE DIHYDROPYRIMIDINE CYANO-SUBSTITUES ET LEUR UTILISATION POUR TRAITER DES MALADIES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2002079169A1

  公开（公告）日：2002-10-10

  The present invention provides compounds of formula (I), formula (I) and pharmaceutically acceptable salts thereof. The formula I compounds induce mitotic arrest thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inducing mitotic arrest.

  本发明提供了式(I)的化合物，式(I)和其药学上可接受的盐。式(I)化合物能够诱导有丝分裂停滞，因此它们可用作抗癌剂。式(I)化合物还可用于治疗其他可以通过诱导有丝分裂停滞来治疗的疾病。
• Novel cyano-substituted dihydropyrimidine compounds and their use to treat diseases
  申请人：——

  公开号：US20030008888A1

  公开（公告）日：2003-01-09

  The present invention provides compounds of formula I 1 and pharmaceutically acceptable salts thereof. The formula I compounds induce mitotic arrest thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inducing mitotic arrest.

  本发明提供了I1式化合物及其药学上可接受的盐。I式化合物诱导有丝分裂停滞，因此它们可用作抗癌剂。I式化合物还可用于治疗其他可以通过诱导有丝分裂停滞来治疗的疾病。
• NOVEL CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES
  申请人：Bristol-Myers Squibb Company

  公开号：EP1373221A2

  公开（公告）日：2004-01-02
• EP1373221A4
  申请人：——

  公开号：EP1373221A4

  公开（公告）日：2004-09-29